The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

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Mechanism related to existing mutagenicity alert Extend existing mutagenicity alert Project strategy Chemical class causing chromosome damage Mechanism not related to existing mutagenicity alert Develop new chromosome damage alert
Developing new alerts In vitro chromosomal aberration data sets Analyse Common toxicophores Prioritise Ranked common toxicophores Gather mechanistic evidence <strong>and</strong> additional examples Mechanism-based structural alerts
Page 1 and 2: The Prediction of Chromosomal Effec
Page 3 and 4: Chromosomal effects • In vitro te
Page 5 and 6: Derek for Windows • Derek for Win
Page 7: Genotoxicity Coverage • Genotoxic
Page 11 and 12: Toxicophore identification • Toxi
Page 13 and 14: Toxicophore identification • Visu
Page 15 and 16: Known active O HN O N H F Toxicopho
Page 17 and 18: Toxicophore development • The nex
Page 19 and 20: Initial toxicophore: O N O N Toxico
Page 21 and 22: O N O HN N OH O O F OH O Alert feat
Page 23 and 24: Results of toxicophore development
Page 25 and 26: Common mechanisms leading to chromo
Page 27 and 28: Chromosomal effect mechanisms Disru
Page 35 and 36: How computer systems are evaluated
Page 37 and 38: Evaluation results • The best res
Page 39 and 40: Combined systems - detailed results
Page 41 and 42: Combined systems - detailed results
Page 43: • Lhasa Limited � Kate Langton

The Prediction of Chromosomal Effects and Their ... - Lhasa Limited

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