The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
The Prediction of Chromosomal Effects and Their ... - Lhasa Limited
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Initial<br />
toxicophore:<br />
O<br />
N<br />
O<br />
N<br />
Toxicophore development<br />
R<br />
Where R =<br />
any heteroatom<br />
Additional<br />
examples included:<br />
O<br />
N<br />
O<br />
HN<br />
N<br />
OH<br />
O<br />
O<br />
F<br />
OH<br />
Capecitabine, a clastogenic<br />
5-fluorocytidine<br />
Underlying<br />
mechanism:<br />
5-Fluorouracils <strong>and</strong> 5fluorocytidines<br />
inhibit<br />
thymidylate synthetase
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