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exsymol's<br />
technology<br />
exsymol<br />
MONACO
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s y<br />
m ol<br />
MONACO<br />
EXSYMOL S.A.M.<br />
SOciété AnOnYME MOnégASquE<br />
located in Monaco’s industrial area, our laboratories, production<br />
research<br />
and storage facilities are spread over 6000 m2<br />
production<br />
logistics<br />
administration<br />
reglementations<br />
information and<br />
communication<br />
reach 1907/2006/ce<br />
clP 1272/2008<br />
SGh<br />
MSDS
sales and development<br />
of active ingredients<br />
innovating and patented<br />
applied research<br />
by a multidisciplinary scientific team, chemical synthesis, biotechnology, molecular<br />
and cellular biology, relying on adapted research equipment in symbiosis with<br />
international scientific culture, regularly applying for discovery patents.<br />
production<br />
supported by high performance industrial equipment dedicated to fine and green<br />
chemistry, over 6000m2, conforming ISO 9001 norms. Computerized production<br />
management, implemented GMPCI (Good Manufacturing Practices for Cosmetic<br />
Ingredients), quality checks of all batch in accordance with pharmaceutical<br />
standards<br />
information<br />
Technical scientific files support: activity, tolerance<br />
and communication<br />
Active ingredients communication is supported by technical data defining their<br />
physico-chemistry.<br />
Tolerance studies were undertaken before products’market launch<br />
Activity studies focus on the efficacy of our products but also on the<br />
understanding of the action mechanisms<br />
EXSYMOL’s technical communication targets the research departments of worldwide<br />
cosmetic companies.<br />
Our reactivity towards our clients’requests relies on a smart team.<br />
EXSYMOL’s promotes its expertise through advertisement in specialized journals,<br />
booths on exhibitions such as In Cosmetics and conference and scientific posters<br />
during scientific congress.<br />
logistics<br />
In conformance with international standards and the newest European directives,<br />
products’shipments comply with clients’ requirements in terms of quality and<br />
timing.<br />
Stocks are available worldwide through our 35 distributors. Representative of<br />
the fact that 50% of our sales are done overseas, we supply more than 150<br />
destinations.<br />
administration-regulation<br />
Fulfillment of regulatory and legislative international norms in order to create and<br />
maintain quality partnership with our clients.<br />
detailed technical literature for the<br />
original actives designed, patented<br />
and manufactured by EXSYMOL are<br />
available upon request<br />
EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02 - mail : exsymol@exsymol.com - www.exsymol.com<br />
e<br />
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TOPICAL TreATmenT<br />
Anti-Aging skin and body care<br />
skIn regeneratIon and<br />
functIonal support<br />
skIn protectIon<br />
InnovatIve<br />
benefIts<br />
Silanols<br />
Extracts<br />
Nature identical Peptoids<br />
Moisturizer and barrier function<br />
Firming<br />
Dermal filler - collagen production<br />
Anti-wrinkles<br />
Even skin tone<br />
Eye contour<br />
Skin energizing<br />
Skin lightener<br />
Anti-dehydration<br />
Microcirculation<br />
Epidermal filler - hyaluronic acid production<br />
Anti-oxidant<br />
Anti-glycation<br />
Free radical protection<br />
DNA protection<br />
Anti-photoaging<br />
Anti-inflammatory<br />
Neuroprotection<br />
Circadian genes synchronization + VIT D<br />
Immuno cutaneous stimulation<br />
Immediate tensing effect<br />
BODY COntOUR<br />
SUn CARE<br />
Firming-elasticity and tightening<br />
Lipolysis activator, slimming, body shapping<br />
Anti orange peel skin<br />
Adipocyte maturation inhibitor<br />
Anti U.V. damages<br />
Anti I.R. damages<br />
Tan activator<br />
Soothing activity<br />
After sun<br />
HAiR AnD nAiL CARE<br />
Hair care: quality and strenghtening<br />
Anti-hair loss<br />
Anti-body hair growth<br />
Nail care: quality and strenghtening<br />
COLOR COSMEtiCS<br />
ALgiSiUM C<br />
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EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02 - mail : exsymol@exsymol.com - www.exsymol.com<br />
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PHYKOSiL 2000<br />
LiPOSiLiOL C<br />
SiLPEARL<br />
J J J J J<br />
Some of our cosmetic ingredients can be incorporated into functional color cosmetic products such as anti-aging foundation cream, eye brow, lipsticks...<br />
Please contact us for any further details.<br />
D.S.H. Cn<br />
LASiLiUM<br />
SiLHYDRAtE C<br />
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ASCORBOSiLAnE C<br />
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tYROSiLAnE C<br />
EXSY-ALginE<br />
ARCt ALg<br />
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gLUtRAPEPtiDE<br />
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J J<br />
CAFEiSiLAnE C<br />
ARgiSiL C<br />
tHEOPHYLLiSiLAnE C<br />
XAntALgOSiL C<br />
ARgiLiP<br />
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nAnOSPHERES 100<br />
EMULZOME<br />
EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02 - mail : exsymol@exsymol.com - www.exsymol.com<br />
J<br />
J<br />
J<br />
J<br />
Subtained delivery carriers: chronocosmetology<br />
CAPiLLiSiL HAUtE<br />
COnCEntRAtiOn<br />
J<br />
J<br />
Stable oil / water nanodispersion without surfactant, optimizing active ingredients bioavailability<br />
J<br />
PRO DSB<br />
J<br />
J J<br />
J<br />
J<br />
J<br />
CAPiCUR 25<br />
J<br />
PHAniLignE<br />
J<br />
ALBAtin<br />
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sIlAnols<br />
SILANOLS<br />
multi benefitS: skin restructuration,<br />
rejuvanation<br />
ALGISIUM C<br />
Methylsilanol mannuronate*<br />
Scientific expertiSe Skin benefitS<br />
innovative lipolySiS:<br />
combines slimming and firming activates<br />
lipolysis citokynes (NO)<br />
- Multiactive.<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Active against most causes.<br />
ARGISIL C<br />
Silanetriol arginate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized Vit C with smart delivery<br />
silicium technology<br />
- Optimal bioavailibility.<br />
- Complementary approach of lipolysis activation.<br />
- Anti-glycation.<br />
- Skin restructuration.<br />
ASCORBOSILANE C<br />
Ascorbyl methylsilanol pectinate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized caffeine with smart delivery<br />
silicium technology<br />
- Cutaneous detoxifier.<br />
- Anti-free radical.<br />
- Favors skin tone radiance.<br />
- Increased cell's membrane resistance against free radicals.<br />
- Optimal bioavailibility.<br />
CAFEISILANE C<br />
Siloxanetriol alginate (and) caffeine*<br />
Scientific expertiSe Skin benefitS<br />
Anti hair loss, improved hair quality and<br />
density<br />
- Global strategy: firming and slimming.<br />
- Synergistic activity of slicium and caffeine.<br />
- Microcirculation stimulation, release of fatty acid, oedema, puffy eyes and dark circles.<br />
- Optimal bioavailibility.<br />
CAPILLISIL HAUTE CONCENTRATION<br />
Silanediol salicylate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized salicylic acid with smart<br />
delivery silicium technology<br />
- High concentration of silicium brought to deep layers of the skin (e.g. hair root).<br />
D.S.B. C<br />
Silanediol salicylate*<br />
Scientific expertiSe Skin benefitS<br />
- Control skin inflammatory reaction.<br />
- Heat shock proteins (HSP) overexpression when required - anti stress activity.<br />
- Enzymatic activity and protein protection against photo-aging.
sIlAnols<br />
Intense and long lasting hydration<br />
Dermal filler, epidermal renewal<br />
Potentialized threalose with smart delivery<br />
silicium technology<br />
More intense and better organized<br />
collagen production<br />
HYDROXYPROLISILANE C N<br />
Methylsilanol hydroxyproline aspartate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized lactic acid with smart<br />
delivery silicium technology<br />
- Intensive and organized skin regeneration.<br />
- Elastin booster.<br />
- More effective use of cellular energetic stock.<br />
- Optimal bioavailibility.<br />
- Microcirculation stimulation.<br />
LASILIUM<br />
Sodium lactate methylsilanol*<br />
Scientific expertiSe Skin benefitS<br />
Oily version of multi functional silicium<br />
technology<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Hydroxyl groups binding water.<br />
- Serine protease regulation for higher tissue moisturization (preserve protein as water fixation sites).<br />
LIPOSILIOL C<br />
Dioleyl tocopheryl methylsilanol (and) oleyl alcohol*<br />
Scientific expertiSe Skin benefitS<br />
Immediate tensing effect while the<br />
silicium technology is restructuring skin<br />
appearance and metabolism.<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
MS HC<br />
Silanetriol (and) hydrolyzed collagen*<br />
Scientific expertiSe Skin benefitS<br />
Natural version of multi functional silicium<br />
technology<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
PHYKOSIL 2000<br />
Asparagopsis armata extract*<br />
Scientific expertiSe Skin benefitS<br />
Precursor form of multi functional silicium<br />
technology (liposoluble or for lacquer use)<br />
D.S.H.C. N<br />
Dimethylsilanol hyaluronate*<br />
Scientific expertiSe Skin benefitS<br />
- Skin restructuration: Silicium affinity as a dermal structural component hydroxyl groups binding water.<br />
- Excellent moisturizing properties.<br />
EPIDERMOSIL<br />
Hyaluronic acid (and) silanetriol*<br />
Scientific expertiSe Skin benefitS<br />
- Keratinocytes stimulation --> proliferation (optimized re-epithelisation) and hyaluronic acid production.<br />
- Epidermis restructuration, fibroblasts cytostimulation.<br />
- Genes stimulation involved in hydration process<br />
(NMF, barrier function water transmembrane channel…).<br />
G.P.S.<br />
Silanetriol trehalose ether*<br />
Scientific expertiSe Skin benefitS<br />
- Osmoregulator capable of substitution of water during extreme dehydration state.<br />
- Increased cell viability when submitted to UV stress.<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Cells metabolism stimulation.<br />
- Anti-inflammation.<br />
PRO DSB<br />
Dimethyl oxobenzo dioxasilane*<br />
Scientific expertiSe Skin benefitS<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Cells metabolism stimulation.<br />
* INCI denomination of main constituent for additive, please refer to complete INCI denomination
sIlAnols<br />
Hygroscopic (water absorption)<br />
combined with silicium technology<br />
Luxurious version of multi functional<br />
silicium technology applied to fresh<br />
pearl protein<br />
Potentialized lysine with smart delivery<br />
silicium technology<br />
THEOPHYLLISILANE C<br />
Methylsilanol carboxymethyl theophylline alginate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized xanthic base with smart<br />
delivery silicium technology<br />
TYROSILANE<br />
Methylsilanol acetyltyrosine*<br />
Scientific expertiSe Skin benefitS<br />
Tan activator - Potentialized tyrosine<br />
with smart delivery silicium technology<br />
XANTALGOSIL C<br />
Acefylline methylsilanol mannuronate*<br />
Scientific expertiSe Skin benefitS<br />
Potentialized xanthic base with smart<br />
delivery silicium technology<br />
SILHYDRATE C<br />
Copper pca mehylsilanol (and) sodium PCA*<br />
Scientific expertiSe Skin benefitS<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Immediate and intense superficial hydration.<br />
SILPEARL<br />
Hydrolyzed pearl (and) silanetriol*<br />
Scientific expertiSe Skin benefitS<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Cells metabolism stimulation.<br />
SILYSIN C4<br />
Silanetriol lysinate*<br />
Scientific expertiSe Skin benefitS<br />
- Anti-glycation activity.<br />
- Skin restructuration: Silicium affinity as a dermal structural component.<br />
- Global strategy: firming and slimming.<br />
- Synergistic activity of silicium and acefylline.<br />
- Microcirculation stimulation, release of fatty acid, oedema, puffy eyes and dark circles.<br />
- Optimal bioavailibility.<br />
- Melanin booster.<br />
- Improves keratinocytes - melanocytes communication.<br />
- Optimal bioavailibility.<br />
- Global strategy: firming and slimming.<br />
- Synergistic activity of silicium and acefylline.<br />
- Microcirculation stimulation, release of fatty acid, oedema, puffy eyes and dark circles.<br />
- Optimal bioavailibility.<br />
EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02 - mail : exsymol@exsymol.com - www.exsymol.com
PEPTOIDS & funcTIOnal acTIvES<br />
PePtoIDs, FUnctIonAl ActIVes IngReDIents nature identical PePtoIDs<br />
Alternative and innovative skin lightener<br />
Skin detoxifier with specific anti-pollution<br />
efficiency<br />
EXSY-ARL<br />
Prolinamidoethyl imidazole*<br />
Scientific expertiSe Skin benefitS<br />
Neuro active-optimizing neuronal endings<br />
self-protection<br />
ALBATIN<br />
Aminoethylphosphinic acid*<br />
Scientific expertiSe Skin benefitS<br />
Photo-aging prevention -<br />
Anti-glycation and transglycation<br />
Biomimetic source of bioavailable cellular<br />
energy<br />
- Limits melanin formation by stabilizing DOPAchrome.<br />
- Melanogenesis inhibitor.<br />
- Higher stability than most tyrosinase inhibitors with the same potential efficacy.<br />
ALISTIN<br />
Decarboxycarnosine HCl*<br />
Scientific expertiSe Skin benefitS<br />
Highly bioavailable lipolytic active designed<br />
using advanced<br />
Nature identical Phytohormones -<br />
Skin protection<br />
- Skin's cells membrane repair after free radicals attacks.<br />
- Anti toxic aldehydes.<br />
- DNA protection.<br />
- Faster cutaneous homeostasis recovery.<br />
- Contractile activity of fibroblasts for deep firming effect.<br />
ARGILIP<br />
Ethylargininoate acetamidomethionamide*<br />
Scientific expertiSe Skin benefitS<br />
AUXISTIM G<br />
Indoleacetyl glutamic acid*<br />
Scientific expertiSe Skin benefitS<br />
Anti-aging chronopeptide<br />
- Induces lipolysis and limits pre adipocytes differentiation.<br />
- Global and powerfull anti-oxidant.<br />
- Synergistic lipolysis activivation with cafeine.<br />
- Neuroprotection.<br />
- High performance anti-oxidant.<br />
- Skin's cells metabolic stimulation.<br />
- Enhanced collagen production.<br />
- Molecule stability.<br />
- Improved skin cells resitance to environmental stress (U.V., free radicals…).<br />
CHRONOCYCLIN<br />
Glutamylamidoethyl imidazole*<br />
Scientific expertiSe Skin benefitS<br />
- Enhanced expression of circadian genes: CLOCK and PER 1.<br />
- Optimized cells defense.<br />
- Optimized cells renewal.<br />
- Vitamin D photo-transformation activation.<br />
EXSY-ALGINE<br />
Acetyl citrull amido arginine*<br />
Scientific expertiSe Skin benefitS<br />
- Anti-oxidant.<br />
- Optimized cell renewal.<br />
- Supply of energetic stock.<br />
- Anti-inflammatory.<br />
- Optimizes lipolytic.<br />
- Synergistic lipolytic activation when combined with caffeine.<br />
- Stops skin free radicals induced oxidative cascade.<br />
- Protects skin cells membranes and integrity.<br />
- Protects skin structural proteins against cross linking (anti-oxidant, anti-glycation).<br />
- Specific chalation of transition metals.<br />
GLISTIN<br />
Glutamylamidoethyl indole*<br />
Scientific expertiSe Skin benefitS<br />
- Anti neurodegenerescence, neuroprotection.<br />
- Improved skin cells resitance to environmental stress (U.V., free radicals…).<br />
- Improved barrier function.<br />
- Reduced skin hyper reactivity.<br />
* INCI denomination of main constituent for additive, please refer to complete INCI denomination
Potentialized and bioavailable extRActs PePtoIDs, FUnctIonAl ActIVes IngReDIents<br />
2nd generation neuro active designed for<br />
higher bioavailability<br />
GLUTRAPEPTIDE<br />
Pyroglutamylamidoethyl indole*<br />
Scientific expertiSe Skin benefitS<br />
Cutaneous immune defense stimulator<br />
- Anti-neurodegenerescence.<br />
- Optimal bioavailibility.<br />
- Lipolytic induction.<br />
- Improved skin cells resitance to environmental stress (U.V., free radicals…).<br />
- Improved barrier function.<br />
IMUDILIN<br />
Glutamylamidoethyl imidazole*<br />
Scientific expertiSe Skin benefitS<br />
Photo-aging prevention - Limits the skin<br />
clinical damaged induced by U.V. and I.R.<br />
- Improved skin's cells communication.<br />
- Effectively restores skin homeostasis.<br />
OTZ 10<br />
Oxothiazolidine*<br />
Scientific expertiSe Skin benefitS<br />
- Scavenger of a large scope of free radicals, oxigen, nitrogen and carbonyl species.<br />
- Complete biological conversion in taurine --> anti-oxidant and osmoregulator.<br />
- Anti U.V. cellular damages: limits apoptosis, epidermal, dermo-epidermic junction and dermal<br />
degradation and inflammation.<br />
- Anti I.R. cellular damages: Mitochondrial protection, optimized epidermal renewal.<br />
Normalizes MMP-1 expression.<br />
- Optimal bioavailibility.<br />
POTENTIALIZED AND BIOAVAILABLE EXTRACTS<br />
Natural extract of a polar red alga offering<br />
energetic strenght<br />
Plant extracts containing high content of<br />
phytosterols<br />
OLEOSTERINES - HYDRUMINES<br />
Centella asiatia - Hops - Licorice - Sage*<br />
Scientific expertiSe Skin benefitS<br />
Natural version of multi fonctional silicium<br />
technology<br />
ARCT'ALG<br />
Chondrus crispus (carrageenan) extract*<br />
Scientific expertiSe Skin benefitS<br />
Curcuma leaves extracts inhibiting 5 alpha<br />
reductase<br />
Specific garlic extract with degradation of the<br />
enzyme responsible for the lasting smell<br />
Natural extract of a brown alga protecting<br />
dehydrated skins<br />
- Increases skin's resistance against extreme conditions.<br />
- Increases ATP level.<br />
- Improves cutaneous metabolism: cytostimulation, healing, lypolysis.<br />
CAPICUR 25<br />
Curcuma longa (turmeric) leaf extract*<br />
Scientific expertiSe Skin benefitS<br />
- Anti-body hair growth.<br />
- Anti-sebborhea.<br />
- Anti-acne.<br />
- Anti-hair loss.<br />
- Rich in sulfur amino acids for hair care products, or oily skins.<br />
- Osmoregulation.<br />
- Moisturization.<br />
- Anti-dehydration.<br />
E.S.A.<br />
Garlic (allium sativum) extract*<br />
Scientific expertiSe Skin benefitS<br />
EXCEL HIM 10<br />
Himantalia elongata extract*<br />
Scientific expertiSe Skin benefitS<br />
- Anti-wrinkles products, stimulation of fibroblast multiplication.<br />
- Stimulation of microcirculation.<br />
PHYKOSIL 2000 ECO<br />
Asparagopsis armata extract*<br />
Scientific expertiSe Skin benefitS<br />
Compatible with<br />
- Skin restructuration: silicium affinity as a dermal as a dermal structural component.<br />
- Cells metabolism stimulation.<br />
- Anti-inflammation.<br />
Hydroglycolic extracts<br />
regular extractS Red vine, Horsetail, Nettle, Arnica, Aloes, Kola nut, Centella asiatica, Cucumber...<br />
* INCI denomination of main constituent for additive, please refer to complete INCI denomination
ORAL tReAtment<br />
NUTRACEUTICS<br />
neUtRAceUtIcs<br />
Silanols<br />
Extracts<br />
Nature identical Peptoids<br />
Protection and reparation range<br />
Nutraceutical supply of organic silicium<br />
Rejuvanation<br />
Anti-glycation<br />
Anti-oxydant<br />
Anti-wrinkles<br />
Phaneres reinforcement<br />
Energiser, ATP<br />
Anti-oxidant<br />
Rejuvanation<br />
CARCININE FG<br />
Scientific expertiSe Skin benefitS<br />
Energiser<br />
Skin protection & repair<br />
Skin restructuration<br />
Skin protection & repair<br />
Skin restructuration<br />
Skin protection & repair<br />
CARCININE FG<br />
J<br />
CHONDRUS<br />
CRISPUS BIOTECH<br />
J<br />
J J<br />
EXSYNUTRIMENT<br />
SILICIQUE<br />
J<br />
J<br />
MS HC (FG)<br />
J<br />
J<br />
J<br />
J<br />
J J<br />
J J<br />
J<br />
J J<br />
J J<br />
- Optimised skin metabolism<br />
- Anti-glycation<br />
- Skin protection & repair<br />
CHONDRUS CRISPUS BIOTECH<br />
Scientific expertiSe Skin benefitS<br />
- Increases ATP rate bioavilable source of energy<br />
- Rejuvanation<br />
EXSYNUTRIMENT SILICIQUE<br />
Scientific expertiSe Skin benefitS<br />
- Organic silicium technology: anti-wrinkles<br />
- Nutraceutical supply of organic silicium<br />
- Anti-glycation<br />
- Phanere reinforcement (hair, nails...)<br />
MS HC (FG)<br />
Scientific expertiSe Skin benefitS<br />
- Organic silicium technology: anti-wrinkles<br />
- Nutraceutical supply of oranic silicium<br />
- Anti-glycation<br />
- Phanere reinforcement (hair, nails...)<br />
EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02 - mail : exsymol@exsymol.com - www.exsymol.com
exsymol<br />
EXSYMOL S.A.M. - 4 avenue Albert II - MC 98000 MONACO<br />
Tel. : +377 92 05 66 77 - Fax : +377 92 05 25 02<br />
E-mail : exsymol@exsymol.com - Internet : http://www.exsymol.com<br />
VERSION BLANC (SUR CYAN)<br />
P12_1296GB1101D<br />
VERSION 100 56 0 34
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