2004 - Instituto de Biotecnología - UNAM

Publicaciones
Wakamiya,T.Kinoshita,T.Hattori,Y.Yamaguchi,Y.Naoki,H.Corzo,G.Nakajima,T.
Study on the structure activity relationships of NPTX-594
In order to elucidate the structure activity relationships of the spider toxin termed NPTX-594, eleven
toxin analogs were designed and synthesized, and their paralytic activities against cricket were tested.
As a result of the present Study, it was clarified that the Lys residue binding to the 1-amino group of 4,8diaza-1,
1 2-dodecanediamine (Dada) in the molecule of NPTX-594 is not an essential requisite for
toxicity, and can be replaced with neutral or basic amino acids Without any considerable loss of the
activity. However, the replacement of the Lys residue with acidic amino acid residues, such as Asp or
Glu, resulted in an extreme loss of the biological activity.
Regresar