UNIVERSITE DE BOURGOGNE U.F.R de MEDECINE Anne ... - TEL

More documents

Recommendations

Info

Ainsi que toute l’équipe <strong>de</strong> l’unité FLAVIC, département Œil et Nutrition, INRA pour m’avoir accueillie : Corinne Joffre, Lionel Bretillon, Niazi Acar, Olivier Ber<strong>de</strong>aux, Bénédicte Buteau, Stéphanie Cabaret, Stéphane Grégoire, Pierre Juanéda, Laurent Leclere, Marie- Annick Maire, Chantal Vicente ainsi que les doctorantes : Agnès André, Véronique Fournier, Coralie Schnebelen, Sabrina Viau et Omega 21 : Valérie Lasseigne et Florent Joffre. Et surtout Lucy Martine pour m’avoir fait partager ses connaissances en chromatographie.
A mes parents, Maman sans toi je n’en serais pas là, A mes grands-parents, A Marie-France et Daniel, A Jean-Marie et Danièle, A Maryline et Romain.
Page 1 and 2: UNIVERSITE DE BOURGOGNE U.F.R de ME
Page 3: J’aimerais également remercier t
Page 7 and 8: SOMMAIRE Liste des figures………
Page 9 and 10: V. LA VOIE DE SIGNALISATION PI3-K/c
Page 11 and 12: LISTE DES FIGURES Figure 1: Coupe d
Page 13 and 14: Figure 57 : Formule chimique de la
Page 15 and 16: ERK : Extracellular signal-Regulate
Page 17 and 18: RAC-PKα : protéine α en relation
Page 19 and 20: CONTEXTE BIBLIOGRAPHIQUE Avant Prop
Page 21 and 22: Rang 1 2 3 4 5 6 7 8 9 10 11 12 13
Page 23 and 24: Cellules musculaires lisses (média
Page 25 and 26: Type I, Lésion initiale Type II, S
Page 27 and 28: CONTEXTE BIBLIOGRAPHIQUE Athéroscl
Page 41 and 42: lumière paroi lumière paroi monoc
Page 43 and 44: lumière paroi Cellules spumeuses m
Page 51 and 52: CONTEXTE BIBLIOGRAPHIQUE Oxystérol
Page 53 and 54: CONTEXTE BIBLIOGRAPHIQUE Oxystérol
Page 55 and 56:
CONTEXTE BIBLIOGRAPHIQUE Oxystérol
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Stérols cellulaires élevés Stér
Page 69 and 70:
Stimuli inflammatoires Figure 22 :
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Figure 23 : Synthèse du cholestér
Page 77 and 78:
Figure 24 : Transformation du chole
Page 79 and 80:
A cholestérol cholest rol MACROPHA
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Cellule normale Stimulus de mort Ap
Page 97 and 98:
CONTEXTE BIBLIOGRAPHIQUE Mort Cellu
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Caspase-12 Caspase-11 Caspase-13 Ca
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
T G Palmitoyl CoA non-oxydé Sérin
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
XBP1 réticulum ARNm XBP1 ERSE Noya
Page 133 and 134:
éticulum PERK BiP Noyau ATF4 eIF2
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Classe I A kinase Adaptateurs Class
Page 141 and 142:
Classe I II III A B Sous-Unités Ca
Page 143 and 144:
A B ligand Récepteur tyrosine kina
Page 145 and 146:
A B Ras GTP récepteur à 7 domaine
Page 147 and 148:
CONTEXTE BIBLIOGRAPHIQUE Voie PI3-K
Page 149 and 150:
• Inhibiteurs de Phosphatases Van
Page 151 and 152:
PH PH Akt Akt Ser 473 PDK1 PDK1 PH
Page 153 and 154:
Protéines BAD C-Raf B-Raf BRCA-1 C
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
TRAVAUX DE RECHERCHE - 119 -
Page 161 and 162:
Figure 47 : Formule chimique de la
Page 163 and 164:
TRAVAUX DE RECHERCHE Les différent
Page 165 and 166:
laser échantillon (X, Y, Z) pinhol
Page 167 and 168:
Analyse orthogonale Décomposition
Page 169:
Article 1 : Analysis of the Fluores
Page 181 and 182:
TRAVAUX DE RECHERCHE Avec les acide
Page 183 and 184:
A B Absorbance longueur d’onde (n
Page 185 and 186:
A B C Fluorescence du donneur Dipô
Page 187 and 188:
TRAVAUX DE RECHERCHE Dans nos condi
Page 189 and 190:
Analytical and Quantitative Cytolog
Page 191 and 192:
Materials and Methods Cell Culture
Page 193 and 194:
analysis, 3 requiring positive fact
Page 195 and 196:
With reference to the presence of 7
Page 197 and 198:
In the case of spectral observation
Page 199 and 200:
References 1. Brown AJ, Jessup W: O
Page 201 and 202:
From Institut National de la Santé
Page 203 and 204:
Filipin III Figure 57 : Formule chi
Page 205 and 206:
Article 3 : 7-Ketocholesterol favor
Page 207 and 208:
88 VEJUX ET AL. favor apoptosis in
Page 209 and 210:
90 VEJUX ET AL. fluorescence emissi
Page 211 and 212:
92 VEJUX ET AL. FIG. 2. Visualizati
Page 213 and 214:
94 VEJUX ET AL. FIG. 4. Effects of
Page 215 and 216:
96 VEJUX ET AL. FIG. 6. Fluorescenc
Page 217 and 218:
98 VEJUX ET AL. peritoneal macropha
Page 219 and 220:
100 VEJUX ET AL. cholesterol oxidat
Page 221 and 222:
TRAVAUX DE RECHERCHE - accumulation
Page 223 and 224:
TRAVAUX DE RECHERCHE ARTICLE 4 : Cy
Page 225 and 226:
Article 4 : Cytotoxic oxysterols in
Page 227 and 228:
ABSTRACT 2 Vejux et al. Oxysterols,
Page 229 and 230:
4 Vejux et al. that 7KC-induced lip
Page 231 and 232:
6 Vejux et al. Identification and q
Page 233 and 234:
RESULTS 8 Vejux et al. Effects of d
Page 235 and 236:
10 Vejux et al. Therefore, during 7
Page 237 and 238:
12 Vejux et al. figure formation on
Page 239 and 240:
14 Vejux et al. induce a caspase-in
Page 241 and 242:
16 Vejux et al. 15 Tabas I (2002) C
Page 243 and 244:
18 Vejux et al. 31 Terrisse AD, Bez
Page 245 and 246:
20 Vejux et al. 46 Kahn E, Vejux A,
Page 247 and 248:
LEGENDS OF FIGURES 22 Vejux et al.
Page 249 and 250:
Fig. 1 % of PI positive cells % of
Page 251 and 252:
A B C D E F G H I Fig. 3 3 µm 3 µ
Page 253 and 254:
Control (18h) 7KC (40 µg/ml, 18h)
Page 255 and 256:
Activité caspase-2 0,160 0,140 0,1
Page 257 and 258:
Article 5 : Effects of caspase inhi
Page 259 and 260:
ABSTRACT Background: 7-ketocholeste
Page 261 and 262:
with the caspase-2 inhibitor z-VDVA
Page 263 and 264:
uffer saline (PBS). Cells were dist
Page 265 and 266:
RESULTS Relationships between caspa
Page 267 and 268:
In the case of 7KC-treated U937 cel
Page 269 and 270:
fluorescence emission) when 7KC-tre
Page 271 and 272:
9 Klinkner AM, Bugelski PJ, Waites
Page 273 and 274:
25 Prunet C, Lemaire-Ewing S, Mén
Page 275 and 276:
Figure 3: Multispectral analysis on
Page 277 and 278:
Control (18 h) 7KC (40 µg/ml,18 h)
Page 279 and 280:
TRAVAUX DE RECHERCHE III. EFFETS DE
Page 281 and 282:
Article 6 : Vitamin E impairs phosp
Page 283 and 284:
ABSTRACT In the present investigati
Page 285 and 286:
autophagic vacuoles, and to assert
Page 287 and 288:
accumulation of phospholipids in ce
Page 289 and 290:
myeloid bodies) excessive accumulat
Page 291 and 292:
on the PI3-K / PDK-1 / Akt signalli
Page 293 and 294:
In situ detection of activated casp
Page 295 and 296:
pm) with a cytospin 4 (Shandon, Che
Page 297 and 298:
Characterization and quantification
Page 299 and 300:
ACKNOWLEDGEMENTS This work was supp
Page 301 and 302:
15 Monier S, Samadi M, Prunet C, De
Page 303 and 304:
34 Kroemer G, Petit P, Zamzami N, V
Page 305 and 306:
52 Khwaja A. Akt is more than just
Page 307 and 308:
LEGENDS OF FIGURES Figure 1: Ultras
Page 309 and 310:
Fig 1 A B C D 2 µm E F 2 µm 2 µm
Page 311 and 312:
% of cells with activated caspases
Page 313 and 314:
Staining with MDC ° Untreated cell
Page 315 and 316:
DISCUSSION Lors du traitement de ce
Page 317 and 318:
DISCUSSION III. Relations figures m
Page 319 and 320:
DISCUSSION (Tabas, 1997a ; 1997b).
Page 321 and 322:
DISCUSSION Concernant le rôle de l
Page 323 and 324:
DISCUSSION secondaire (par activati
Page 325 and 326:
DISCUSSION phospholipides poly-insa
Page 327 and 328:
Dans leur ensemble, les travaux ré
Page 329 and 330:
Sur des cellules traitées par du 7
Page 331 and 332:
A • Acehan D, Jiang X, Morgan DG,
Page 333 and 334:
• Asanuma K, Tanida I, Shirato I,
Page 335 and 336:
• Bombeli T, Karsan A, Tait JF, H
Page 337 and 338:
• Castelli WP. (1988) Cholesterol
Page 339 and 340:
D • Dacheux D, Toussaint B, Richa
Page 341 and 342:
• Earnshaw WC, Martins LM, Kaufma
Page 343 and 344:
G • Garcia-Cruset S, Carpenter KL
Page 345 and 346:
• Hariri M, Millane G, Guimond MP
Page 347 and 348:
• Hulley S, Grady D, Bush T, Furb
Page 349 and 350:
• Kahn E, Vejux A, Dumas D, Monta
Page 351 and 352:
• Klionsky DJ. (2005) The molecul
Page 353 and 354:
• Lagace TA, Byers DM, Cook HW, R
Page 355 and 356:
• Lesauskaitè V, Ivanovienè L,
Page 357 and 358:
• Lutjohann D, Breuer O, Ahlborg
Page 359 and 360:
• Mengesdorf T, Althausen S, Oben
Page 361 and 362:
• Nguyen DH, Taub DD. (2003) Memb
Page 363 and 364:
• Otsu M, Hiles I, Gout I, Fry MJ
Page 365 and 366:
• Piccotti JR, LaGattuta MS, Knig
Page 367 and 368:
• Robenek H, Schmitz G. (1988) Ca
Page 369 and 370:
• Samali A, Cai J, Zhivotovsky B,
Page 371 and 372:
• Shimabukuro M, Wang MY, Zhou YT
Page 373 and 374:
• Sudhof TC, Russel DW, Brown MS,
Page 375 and 376:
• Tschopp J, Irmler M, Thome M. (
Page 377 and 378:
W • Wagner KW, Engels IH, Deverau
Page 379 and 380:
Z • Zamzami N, Kroemer G. (2001)
Page 381 and 382:
2006 06.1 - Kahn E, Vejux A, Menetr
Page 383 and 384:
-Investigation of lipid interaction
Page 385 and 386:
ABSTRACT Atherosclerosis is a compl
show all

UNIVERSITE DE BOURGOGNE U.F.R de MEDECINE Anne ... - TEL

Create successful ePaper yourself

Delete template?

Save as template?