Réponses immunitaires et progression tumorale I) Inflammation ...

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TILs Lymphocytes infiltrant les tumeurs Effecteurs/régulateurs Histologie des tumeurs solides No4on de micro-‐environnement tumoral Immune Myeloid derived cells: - Immune inflammatory cells: TAM (M1-type) Mastocytes/ neutrophiles/ DC immunogéniques - Immune regulatory cells: TAM (M2type), MDSC, DC tolérogéniques
Normal epithelium Normal mammary 4ssue Albini, 2007 ; Tlsty, 2006 Epithelium Histologie des tumeurs solides Stroma Carcinoma Mammary carcinoma Stroma Tumor isl<strong>et</strong>s Ac4vated fibroblasts → Strong produc4on of ECM proteins
Page 1 and 2: Réponses immunitaires et progressi
Page 3 and 4: Huit propriétés intrinsèques The
Page 5: Polarisa4on des T CD4
Page 9: Régula4on de l’infalmma4on par l
Page 12 and 13: DC, Mph,… Lymphocytes non convent
Page 14 and 15: Rôle néga4f de l’IL-‐17 sur
Page 16 and 17: Inflamma4on et cancer: sta4s4ques L
Page 18 and 19: Inflamma4on et progression tumorale
Page 20 and 21: Immunosurveillance et “sélec4on
Page 22 and 23: Cell. 2010 March 19; 140(6): 883-89
Page 24 and 25: Injection de cellules tumorales A (
Page 26 and 27: In vitro, analyse de la cytotoxicit
Page 28 and 29: HLA-C2 Affinité forte KIR2DL1 CD15
Page 30 and 31: NKG2D et les ligands MICA/B Découv
Page 32 and 33: (2) Cellule T CD4 naïve Ac4va4on d
Page 35 and 36: Ac4va4on des lymphocytes T cytotoxi
Page 37 and 38: An4gène de tumeur MAGE (melanoma a
Page 40 and 41: DAMPs • permettent la détection
Page 42 and 43: DAMPs extracellulaires
Page 44 and 45: HMGB1: high-mobility group box 1 pr
Page 46 and 47: DAMPs intracellulaires Favorisent l
Page 48 and 49: Les lymphocytes effecteurs migrent
Page 50 and 51: Echappement immunitaire Treg MDSC P
Page 52 and 53: III) Mécanismes de l’échappemen
Page 54 and 55: PD-‐L1 PD-L1 (ou ligand 1 du r
Page 56 and 57:
Induc4on de cellules immunosuppress
Page 58 and 59:
Tumeur TAM: tumor associated macrop
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Réponses immunitaires et progression tumorale I) Inflammation ...

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