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LINEE DI RICERCA • Studio delle basi morfologiche e biomolecolari dell’invecchiamento del muscolo scheletrico e pianificazione di nuove strategie terapeutiche e di intervento sociale sul paziente anziano miopatico. • Studio della capacità rigenerativa delle cellule satelliti nel muscolo scheletrico del paziente con Sclerosi Laterale Amiotrofica e Malattia di Kennedy. • Studio di marcatori diagnostici delle miopatie infiammatorie. • Studio delle miopatie da statine, in particolare della suscettibilità genetica al danno muscolare da farmaci ipocolesterolemizzanti. • Studio delle basi morfologiche e biomolecolari delle alterazioni del muscolo liscio viscerale e pianificazione di nuove strategie terapeutiche per le patologie connesse a tali alterazioni a carico dell’apparato gastro-enterico e urinario. FONTI SCIENTIFICHE DI RIFERIMENTO Neuromuscular Disease Center- Washington University http://neuromuscular.wustl.edu/ The Cochrane Library: Evidence for Healthcare Decision Making http://www3.interscience.wiley.com/cgi-bin/mrwhome/106568753/HOME Clinical Evidence http://clinicalevidence.bmj.com/ceweb/conditions/index.jsp Trip Database. Turning research into practice http://www.tripdatabase.com/index.html Evidence-Based Medicine Guidelines http://ebmg.wiley.com/ebmg/ltk.koti BIBLIOGRAFIA 1. Allsop KG, Ziter FA. Loss of strength and functional decline in Duchenne’s Dystrophy. Arch Neur 1981;38:406- 411. 2. Armitage J. The safety of statins in clinical practice. Lancet 2007;379(9601):1781-1790. 3. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Eng J Med 1975; 292(7):344-347. 4. Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Eng J Med 1975; 292(8):403- 407. 5. Brooke MH, Fenichel GM, Griggs RC et al. Duchenne Muscular Distrophy: pattern of clinical progression and effects of supportive therapy. Neurology 1989;39:475-481. 6. Dalakas MC. Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med 1991; 325(21):1487- 1498. 7. De Giorgio R, Camilleri M. Human enteric neuropathies: morphology and molecular pathology. Neurogastroenterology and Motility 2004; 16: 515-531. 8. De Giorgio R, Seri M, van Eys G. Deciphering chronic intestinal pseudo-obstruction: do mice help to solve the riddle? Gastroenterology 2007;133:2052-2055. 9. Di Mauro S and Schon EA. Mithocondrial DNA mutations in human disease. Am J Med Genet 2001;106: 18-26. 16
10. Di Nardo G, Blandizzi C, Volta U, Colucci R, Stanghellini V, Barbara G, Del Tacca M, Tonini M, Corinaldesi R, De Giorgio R. Review article: molecular, pathological and therapeutic features of human enteric neuropathies. Aliment Pharmacol Ther 2008; 28: 25-42. 11. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 2007;28:2375–2414. 12. Fanin M, Nascimbeni AC, Fulizio L, Angelini C. The frequency of limb girdle muscular dystrophy 2A in northeastern Italy. Neuromuscul Dirsord 2005;15(3):218-224. 13. Fathi M, Lundberg IE, Tornling G. Pulmonary complications of polymyositis and dermatomyositis. Semin Respir Crit Care Med 2007;28(4):451-458. 14. Flachenecker P. Epidemiology of neuroimmunological diseases. J Neurol 2006;253 (Suppl 5): V/2-V/8. 15. Fuglsang-Frederiksen A. The role of different EMG methodsin evaluating myopathy. Clin Neurophysiol 2006;117/6):1173-1189. 16. Gilhuis HJ, ten Donkelaar HJ, Tanke RB, Vingerhoets DM, Zwarts MJ, Verrips A, Gabreëls FJ. Nonmuscolar involvement in merosine-negative congenital muscolar dystrophy. Pediatr Neurol. 2002 Jan;26(1):30-6. 17. Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment. Panel III. Guidelines. J Am Coll Cardiol 2004;44:720-32. 18. Izzo KL, Aravabhumi S. Clinical electromyography. Priciples and practice. Clin Pediatr Med Surg 1990;7(1):179-194. 19. Jacobson TA. Toward “Pain-Free” Statin Prescribing: Clinical Algorithm for Diagnosis and Management of Mialgia. Mayo Clinic Proc 2008;83(6):687-700. 20. Liguori R, Fuglsang-Frederiksen A, Nix W, Fawcett PR, Andersen K. Electromyography in myopathy. Neurophysiol Clin 1997;27(33):200-203. 21. Lindermann E et al. Quadriceps strength and timed motor performances in myotonic dystrophy Charcot –Marie- Tooth disease, and healthy subjects. Clin Rehabil 1998;12:127-135. 22. Lindermann E et al. strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: A Randomized Clinical Trial. Arch Phys Med Rehabil;1993,76:612-620. 23. Lodi R and Taivassalo T. Phosphorus MR spectroscopy in the clinical investigation of muscle disorders. In: Clinical evaluation and diagnostic tests for neuromuscular disorders. Bertorini T Ed. Butterworth-Heinemann Publishers 2002:503-534. 24. McKenney JM. Statins, Cardiovascular Disease, and Drug Safety. Am J Card 2006;87(A):1c-97c. 25. Mercuri E, Pichiecchio A, Allsop J, Messina S, Pane M, Muntoni F. Muscle MRI in inherited neuromuscular disorders: past, present, and future. J Magn Reson Imaging. 2007;25:433-40. 26. Milner-Brown HS et al. Muscle strenghtening through high resistence weight training in patients with neuromuscular disorders. Arch Phys Med Rehabil. 1988;69:14-19. 27. Mochimaru H, Kawamoto M, Enomoto T, Saitoh Y, Abe S, Nei T, Fukuda Y, Kudoh S. Transbronchial biopsy is clinically useful in classifying patients with interstitial pneumonia associated with polymyositis and dermatomyositis. Respirology 2008; 13(6):863-870. 28. Molokhia M, McKeigue, Curcin V, Majeed A. Statin induced myopathy and myalgia. Time trend analysis and comparison of risk associated with statin class from 1991-2006. PloSone 2008;3(6)2522:1-4. 29. Nirkko AC, Rosler KM, Hess CW. Sensitivity and specificity of needle electromyography: a prospective study comparing automated interference pattern analysis with single motor unit potential analysis. Electroencephalogr Clin Neurophysiol 1995;97(1):1-10. 30. Sackley L, Disler PB, Turner-Stokes L, Wade DT. Rehabilitation intervention for foot drop in neuromuscular disease. Cochrane Database System Review, 2007 April 18. 31. Saneto RP, Friedman SD, Shaw DW. Neuroimaging of mitochondrial disease. Mitochondrion. 2008 May 23. [Epub ahead of print]. 17
Page 1 and 2: Università Degli Studi di Bologna
Page 3 and 4: INTRODUZIONE Le malattie neuro-musc
Page 5 and 6: GRUPPO DI LAVORO Cognome e Nome Tel
Page 7 and 8: Nota 1 Nota 3 Esame isto-citopatolo
Page 9 and 10: Visita Neurologica e Elettromiograf
Page 11 and 12: 2) nel caso di una sospetta miopati
Page 13 and 14: come essi siano colpiti dai differe
Page 15: non uso [Vignos 1966] ma possono ac

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