15. estudo histomorfometrico da reparação óssea em ratos após o ...

ABSTRACT
This study was developed with the intention to evaluate histomorphometric
bone repairing in skull defects created in Wistar rats, above the critical limit
using synthetic biomaterials (hydroxyapatite ceramic + β-tricalcium phosphate).
Were used in the study 18 rats were randomly divided into three groups G1, G2
and G3, with 6 animals each. The study was paired with defect created in the
parietal bone on each side of the median sagittal suture of the animal, where
the left side corresponded to the experiment, Group A, (filled with biomaterial of
synthetic origin) and the right to control, subgroup B, ( filled by blood clot). The
specimens were sent for histological examination by conventional light
microscopy, at 15, 30 and 45 days, which corresponded to the G1, G2 and G3.
The results from these images were submitted to Fisher Exact test for
comparison between groups and the Mann-Whitney to compare groups for
subgroups, evaluating bone repair (quantification of newly formed bone matrix).
We used SPSS (Statistical Package for Social Sciences) 13.0 for Windows, and
statistical analysis with significance level of 5%. From the results it was
concluded that although not statistically significant, the bone defects are
submitted to the biomaterial showed better bone healing in the control group.
Key-words: Bone Regeneration. Biocompatible Materials. Rats