TEYXOS 172 3/17/09 11:13 AM Page 3 - μ. πιτσιλιδης α.ε.
TEYXOS 172 3/17/09 11:13 AM Page 3 - μ. πιτσιλιδης α.ε.
TEYXOS 172 3/17/09 11:13 AM Page 3 - μ. πιτσιλιδης α.ε.
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
<strong>TEYXOS</strong> <strong><strong>17</strong>2</strong> 3/<strong>17</strong>/<strong>09</strong> <strong>11</strong>:14 <strong>AM</strong> <strong>Page</strong> 40<br />
Ε Ι Δ Ι Κ Ο Θ Ε Μ Α<br />
Αλλ<strong>α</strong>γές του τρόπου ζωής<br />
κ<strong>α</strong>ι λιπίδι<strong>α</strong><br />
40 / MEDICAL EXPRESS / TEYXOΣ <strong><strong>17</strong>2</strong> / ΜΑΡΤΙΟΣ 20<strong>09</strong><br />
Από τον Michael H. Crawford, MD Professor<br />
of Medicine, Chief of Clinical Cardiology,<br />
University of California, San Francisco<br />
Πηγή: Becker DJ, et al. Simvastatin vs<br />
therapeutic lifestyle changes and supplements:<br />
randomized primary prevention trial. Mayo<br />
Clin Proc. 2008; 83: 758-764.<br />
Π<strong>α</strong>ρότι οι στ<strong>α</strong>τίν<strong>ε</strong>ς <strong>μ</strong><strong>ε</strong>ιώνουν τ<strong>α</strong> συ<strong>μ</strong>βά<strong>μ</strong><strong>α</strong>τ<strong>α</strong><br />
στ<strong>ε</strong>φ<strong>α</strong>νι<strong>α</strong>ί<strong>α</strong>ς νόσου στους<br />
<strong>α</strong>σθ<strong>ε</strong>ν<strong>ε</strong>ίς στους οποίους <strong>ε</strong>νδ<strong>ε</strong>ίκνυντ<strong>α</strong>ι,<br />
πολλοί προτι<strong>μ</strong>ούν ν<strong>α</strong> δοκι<strong>μ</strong>άσουν<br />
<strong>α</strong>λλ<strong>α</strong>γές του τρόπου ζωής π<strong>α</strong>ρά ν<strong>α</strong><br />
πάρουν φάρ<strong>μ</strong><strong>α</strong>κ<strong>α</strong>. Έτσι, οι Becker κ<strong>α</strong>ι συν<strong>ε</strong>ργάτ<strong>ε</strong>ς<br />
<strong>α</strong>πό το π<strong>α</strong>ν<strong>ε</strong>πιστή<strong>μ</strong>ιο της Pennsylvania<br />
τυχ<strong>α</strong>ιοποίησ<strong>α</strong>ν 74 <strong>α</strong>σθ<strong>ε</strong>ν<strong>ε</strong>ίς <strong>μ</strong><strong>ε</strong> υπ<strong>ε</strong>ρλιπιδ<strong>α</strong>ι<strong>μ</strong>ί<strong>α</strong>,<br />
που πληρούσ<strong>α</strong>ν τ<strong>α</strong> κριτήρι<strong>α</strong> ATP ΙΙΙ γι<strong>α</strong><br />
φ<strong>α</strong>ρ<strong>μ</strong><strong>α</strong>κ<strong>ε</strong>υτική <strong>α</strong>γωγή, σ<strong>ε</strong> σι<strong>μ</strong>β<strong>α</strong>στ<strong>α</strong>τίνη 40 mgr<br />
η<strong>μ</strong><strong>ε</strong>ρησίως ή <strong>α</strong>λλ<strong>α</strong>γές του τρόπου ζωής που<br />
π<strong>ε</strong>ριλά<strong>μ</strong>β<strong>α</strong>ν<strong>α</strong>ν ρύζι κόκκινης <strong>μ</strong><strong>α</strong>γιάς (red yeast<br />
rice) κ<strong>α</strong>ι ιχθυέλ<strong>α</strong>ιο. Το κύριο τ<strong>ε</strong>λικό ση<strong>μ</strong><strong>ε</strong>ίο<br />
ήτ<strong>α</strong>ν η LDL χοληστ<strong>ε</strong>ρόλη. Από τη <strong>μ</strong><strong>ε</strong>λέτη <strong>α</strong>ποκλ<strong>ε</strong>ίστηκ<strong>α</strong>ν<br />
οι <strong>α</strong>σθ<strong>ε</strong>ν<strong>ε</strong>ίς <strong>μ</strong><strong>ε</strong> γνωστοί στ<strong>ε</strong>φ<strong>α</strong>νι<strong>α</strong>ί<strong>α</strong><br />
νόσο κ<strong>α</strong>ι <strong>ε</strong>κ<strong>ε</strong>ίνοι <strong>μ</strong><strong>ε</strong> <strong>α</strong>ντ<strong>ε</strong>νδ<strong>ε</strong>ίξ<strong>ε</strong>ις γι<strong>α</strong> στ<strong>α</strong>τίν<strong>ε</strong>ς<br />
ή γι<strong>α</strong> άσκηση. Η π<strong>α</strong>ρέ<strong>μ</strong>β<strong>α</strong>ση στον τρόπο<br />
ζωής π<strong>ε</strong>ριλά<strong>μ</strong>β<strong>α</strong>ν<strong>ε</strong> <strong>ε</strong>πίσης <strong>μ</strong>ί<strong>α</strong> συνάντηση 3,5<br />
ωρών <strong>α</strong>νά <strong>ε</strong>βδο<strong>μ</strong>άδ<strong>α</strong> <strong>μ</strong><strong>ε</strong> <strong>μ</strong>έλη της ο<strong>μ</strong>άδ<strong>α</strong>ς<br />
π<strong>ε</strong>ρίθ<strong>α</strong>λψης. Στην ο<strong>μ</strong>άδ<strong>α</strong> της στ<strong>α</strong>τίνης έγιν<strong>ε</strong><br />
π<strong>α</strong>ρ<strong>α</strong>δοσι<strong>α</strong>κή συ<strong>μ</strong>βουλ<strong>ε</strong>υτική <strong>μ</strong>όνο <strong>μ</strong>ί<strong>α</strong> φορά,<br />
η οποί<strong>α</strong> π<strong>ε</strong>ριλά<strong>μ</strong>β<strong>α</strong>ν<strong>ε</strong> προ<strong>ε</strong>κτυπω<strong>μ</strong>ένο υλικό.<br />
Η <strong>μ</strong>όνη ση<strong>μ</strong><strong>α</strong>ντική δι<strong>α</strong>φορά στ<strong>α</strong> <strong>α</strong>ρχικά χ<strong>α</strong>ρ<strong>α</strong>κτηριστικά<br />
ήτ<strong>α</strong>ν ότι οι <strong>α</strong>σθ<strong>ε</strong>ν<strong>ε</strong>ίς της ο<strong>μ</strong>άδ<strong>α</strong>ς<br />
π<strong>α</strong>ρέ<strong>μ</strong>β<strong>α</strong>σης στον τρόπο ζωής ήτ<strong>α</strong>ν κ<strong>α</strong>τά <strong>μ</strong>έσο<br />
όρο β<strong>α</strong>ρύτ<strong>ε</strong>ροι (88 έν<strong>α</strong>ντι 81 Kgr).<br />
Αποτ<strong>ε</strong>λέσ<strong>μ</strong><strong>α</strong>τ<strong>α</strong>: Το σω<strong>μ</strong><strong>α</strong>τικό βάρος <strong>μ</strong><strong>ε</strong>ιώθηκ<strong>ε</strong><br />
π<strong>ε</strong>ρισσότ<strong>ε</strong>ρο στην ο<strong>μ</strong>άδ<strong>α</strong> <strong>α</strong>λλ<strong>α</strong>γής τρόπου<br />
ζωής (4,7 έν<strong>α</strong>ντι 0,3 Kgr, p < 0,001). Η<br />
<strong>α</strong>ρτηρι<strong>α</strong>κή πί<strong>ε</strong>ση <strong>μ</strong><strong>ε</strong>ιώθηκ<strong>ε</strong> <strong>ε</strong>ξίσου κ<strong>α</strong>ι στις δύο<br />
ο<strong>μ</strong>άδ<strong>ε</strong>ς. Η LDL χοληστ<strong>ε</strong>ρόλη <strong>μ</strong><strong>ε</strong>ιώθηκ<strong>ε</strong> κ<strong>α</strong>ι<br />
στις δύο ο<strong>μ</strong>άδ<strong>ε</strong>ς (-67 έν<strong>α</strong>ντι -64 mgr/dL) <strong>α</strong>λλά<br />
δ<strong>ε</strong>ν διέφ<strong>ε</strong>ρ<strong>ε</strong> <strong>μ</strong><strong>ε</strong>τ<strong>α</strong>ξύ τους. Τ<strong>α</strong> τριγλυκ<strong>ε</strong>ρίδι<strong>α</strong><br />
<strong>μ</strong><strong>ε</strong>ιώθηκ<strong>α</strong>ν π<strong>ε</strong>ρισσότ<strong>ε</strong>ρο στην ο<strong>μ</strong>άδ<strong>α</strong> <strong>α</strong>λλ<strong>α</strong>γής<br />
τρόπου ζωής (-51 vs -14 mgr/dL, p =
Change language