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Anabolic resistance: a road map to malnutrition

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AGING<br />

HORMONE<br />

DEFICIENCY<br />

OR EXCESS<br />

Sarcopenia of aging<br />

Cancer cachexia<br />

Chronic renal failure<br />

Rheuma<strong>to</strong>id arthritis<br />

Osteoarthritis<br />

HIV/AIDS<br />

COPD<br />

Anorexia<br />

Male hypogonadism<br />

Obesity (weight loss)<br />

LOW PROTEIN – ENERGY<br />

INTAKE<br />

MECHANISMS OF ANABOLIC RESISTANCE<br />

IN CHRONIC CONDITIONS<br />

CHRONIC CONDITIONS WITH ANABOLIC RESISTANCE<br />

HYPOPERFUSION<br />

HYPOXIA<br />

Corticosteroid administration<br />

(transplant, au<strong>to</strong>immune<br />

disease)<br />

Coronary artery disease<br />

Congestive heart failure<br />

Liver Cirrhosis<br />

Type 1 and 2 diebetes mellitus<br />

Hip fracture<br />

Disuse atrophy<br />

(spinal cord injury, denervation,<br />

bed rest, microgravity)<br />

OXIDATIVE STRESS<br />

AND<br />

CHRONIC<br />

INFLAMMATION<br />

CANCER<br />

CACHECTIC<br />

FACTORS<br />

LOW PHYSICAL<br />

ACTIVITY

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