Anabolic resistance: a road map to malnutrition

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A 5-Year Cohort Study of the Effects of High Protein Intake on Lean Mass and Bone Mineral Content in Elderly Postmenopausal Women J Bone Miner Res. 2009 • relationship between baseline protein intake and lean mass and bone mineral content (DEXA) • 862 elderly postmenopausal women (mean age: 75 yrs) • 5 years follow-up 6 4 2 0 whole body lean mass whole body bone mineral density Percent differences between the lowest (< 66 g/d), and the highest (> 87 g/d) tertile of protein intake A higher protein intake is associated with long term beneficial effects on muscle mass and size and bone mass in elderly women
Whole-body Whole-body Whole-body protein loss (kg (kg (kg / 2 weeks) PROTEIN REQUIREMENT IN CRITICAL ILLNESS AT ADEQUATE ENERGY INTAKE Wolfe et al., Ann Surg 1983; Ishibashi et al., Crit Care Med 1998 0 -0.5 -1 -1.5 -2 Hoffer Am J Clin Nutr 2003 g protein / kg IBW per day ≈ 0.7 ≈ 1.0 ≈ 1.5 ≈ 2.2
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Anabolic resistance: a road map to malnutrition

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