Anabolic resistance: a road map to malnutrition
Anabolic resistance: a road map to malnutrition
Anabolic resistance: a road map to malnutrition
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Percent loss of lean body mass<br />
Long-term bed-rest<br />
(60 days) in healthy<br />
female volunteers<br />
WISE 2005 (Women<br />
International Space Simulation<br />
for Exploration)<br />
0<br />
-1<br />
-2<br />
-3<br />
-4<br />
-5<br />
-6<br />
-7<br />
-8<br />
-9<br />
-10<br />
ESA/CNES/NASA/CSA<br />
BR<br />
15 days<br />
*<br />
BR<br />
31 days<br />
Control<br />
High-protein diet<br />
BR<br />
43 days<br />
SKELETAL MUSCLE<br />
ATROPHY (DEXA)<br />
N = 8<br />
N = 6<br />
BR<br />
60 days<br />
Bed rest effect: p = 0.01; bed rest × diet interaction: p = 0.01<br />
(repeated measures ANCOVA)<br />
ADAPTATION<br />
(20 days)<br />
Ambula<strong>to</strong>ry<br />
conditions<br />
Ambula<strong>to</strong>ry<br />
conditions<br />
EXPERIMENTAL PERIOD<br />
(60 days)<br />
“Bed Rest”- Eucaloric diet<br />
1 g protein / (kg · day)<br />
non-protein calories <strong>to</strong> nitrogen ratio<br />
134±3 kcal/g<br />
“Bed Rest”- Eucaloric diet<br />
1.4 g protein / (kg · day)<br />
0.16 g BCAA / (kg · day)<br />
non-protein calories <strong>to</strong> nitrogen ratio<br />
86±2 kcal/g<br />
REABILITATION<br />
(20 days)<br />
Ambula<strong>to</strong>ry<br />
conditions<br />
Ambula<strong>to</strong>ry<br />
conditions<br />
High-protein<br />
CARDIAC ATROPHY (MRI)<br />
Dorfman et al., J Appl Physiol 2007
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