Anabolic resistance: a road map to malnutrition

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Percent loss of lean body mass Long-term bed-rest (60 days) in healthy female volunteers WISE 2005 (Women International Space Simulation for Exploration) 0 -1 -2 -3 -4 -5 -6 -7 -8 -9 -10 ESA/CNES/NASA/CSA BR 15 days * BR 31 days Control High-protein diet BR 43 days SKELETAL MUSCLE ATROPHY (DEXA) N = 8 N = 6 BR 60 days Bed rest effect: p = 0.01; bed rest × diet interaction: p = 0.01 (repeated measures ANCOVA) ADAPTATION (20 days) Ambulatory conditions Ambulatory conditions EXPERIMENTAL PERIOD (60 days) “Bed Rest”- Eucaloric diet 1 g protein / (kg · day) non-protein calories to nitrogen ratio 134±3 kcal/g “Bed Rest”- Eucaloric diet 1.4 g protein / (kg · day) 0.16 g BCAA / (kg · day) non-protein calories to nitrogen ratio 86±2 kcal/g REABILITATION (20 days) Ambulatory conditions Ambulatory conditions High-protein CARDIAC ATROPHY (MRI) Dorfman et al., J Appl Physiol 2007
Adjusting for covariates (age at inclusion, BMI at inclusion, and BMD of the femoral neck at inclusion) a significant (P < 0.05) difference was seen in the response to training of bone mineral density between the two groups. Strength improvements from 6 to 24 wk, a significant difference was apparent between groups: nutrient group, 9±3% vs. control, 1±2% (P < 0.05).
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Anabolic resistance: a road map to malnutrition

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