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Anabolic resistance: a road map to malnutrition

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percent<br />

50<br />

25<br />

0<br />

Meal-induced<br />

stimulation of protein synthesis<br />

* *<br />

AMB BR AMB BR<br />

Eucaloric diet Hypocaloric diet<br />

micromol leucine/kh/min<br />

kg<br />

0.30<br />

0.25<br />

0.20<br />

0.15<br />

0.2<br />

-0.2<br />

-0.6<br />

-1<br />

-1.4<br />

CHANGES IN<br />

LEAN MASS (DEXA)<br />

Eucaloric<br />

Ambula<strong>to</strong>ry<br />

Hypocaloric<br />

Ambula<strong>to</strong>ry<br />

Eucaloric<br />

Hypocaloric<br />

Bed Rest<br />

Bed Rest<br />

Protein catabolism<br />

in the fasting state<br />

AMB BR AMB BR<br />

Eucaloric diet Hypocaloric diet<br />

*<br />

*

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