Anabolic resistance: a road map to malnutrition

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J. Clin. Invest. 95:811-819, 1995 MUSCLE PROTEIN SYNTHESIS * * nmol /min x 100 ml leg vol. 800 700 600 500 400 300 200 100 0 ml/min/100ml leg vol. INWARD AMINO ACID TRANSPORT * * (F (FM,A) M,A) PHE LEU LYS ALA BASAL INSULIN LEG BLOOD FLOW 5 4 3 2 1 0 * BAS INS * *
RELATIONSHIPS BETWEEN INSULIN-MEDIATED STIMULATION OF MUSCLE BLOOD FLOW AND PROTEIN SYNTHESIS (leg or forearm A-V balance technique combined with stable iso<strong>to</strong>pes) Mean changes in muscle protein protein synthesis (nmol/min/100ml leg vol) 500 400 300 200 100 0 R 2 = 0.9318 -20 -100 0 20 40 60 Mean changes in leg blood flow (ml/min/100ml leg vol) 80 Moeller-Loswick et al., AJP 1994 Moeller-Loswick et al., AJP 1995 Zanetti et al., Cl Science 1999 Tessari et al., JCI 1991 Arfdisson et al., AJP 1991 Meek et al., Diabetes 1998 Denne et al., AJP 1991 Biolo et al., JCI 1995 Gelfand & Barrett, JCI 1987 Louard et al., JCI 1992 Biolo et al, Diabetes 1999
Page 1 and 2: The Danish Society of Clinical Nutr
Page 3: EFFECTS OF AMINO ACID INFUSION ON S
Page 6 and 7: F M,A / F IN F V,A MODEL OF LEG MUS
Page 10 and 11: MUSCLE PROTEIN SYNTHESIS ml/min/100
Page 12 and 13: Am J Physiol. 1995 Mar;268(3 Pt 1):
Page 14 and 15: nmol PHE/min x 100 ml leg vol. Regu
Page 16: EXERCISE INACTIVITY ? INCREASED ANA
Page 19 and 20: Metabolic Effects of Very Low Calor
Page 21 and 22: MUSCLE MASS NORMAL NUTRITIONAL STAT
Page 23 and 24: AGING HORMONE DEFICIENCY OR EXCESS
Page 25 and 26: percent 50 25 0 Meal-induced stimul
Page 27 and 28: percent 40 30 20 10 0 PREVALENCE OF
Page 29 and 30: ∆ (kg) 2 Changes in fat mass (bio
Page 31 and 32: ∆ (kg) Changes in fat mass (bioim
Page 33 and 34: 2115 cancer patients 15% obesity 15
Page 36 and 37: Percent loss of lean body mass Long
Page 38: The majority of sick elderly patien
Page 41 and 42: Whole-body Whole-body Whole-body pr
Page 43: Medications and nutraceuticals to c
Page 46 and 47: 90-day strength training increased
Page 48: iolo@units.it Department of Interna

Anabolic resistance: a road map to malnutrition

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