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Appendix IV Epinephrine β 2 Receptors Skeletal muscles Arteriolar vasodilation Norepinephrine α 2 Receptors Renal, splachnic and cutaneous beds arteriolar vasoconstriction Heart α 1 Receptors ↑ Contractile force β 1 Receptors ↑ Contractile force Fig. 2: Cardiovascular Control Mechanisms Mediated by Autonomic Activity To the Heart of the Matter ↑ Conduction volocity Cardiac Effect ↑ cardiac output References: Guyton (1986), Berne et al. (1998) & Paulson et al. (1996) 56
Appendix V Cardiovascular Activity of the Glucocorticoids To the Heart of the Matter The catabolic Glucocorticoids are produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH) release from the anterior pituitary gland. Release of ACTH is mediated by corticotropin releasing factor (CRF), which is released from the hypothalamus. Glucocorticoid (particularly cortisol) activity upon the Cardiovascular system: Sustains myocardial performance Facilitates the vasoconstrictive activities of the catecholamines and angiotensin II Decreases the production of the vasodilator prostaglandins and reduces vascular endothelium permeability. Increases circulatory cholesterol Increases circulatory triglyceride Production of glucocorticoids occurs in response to stress and it has been recognised for nearly a century that this is a two-way process, as increased glucocorticoid levels can cause mood disturbances. Table 3: Cardiovascular Activity of the Glucocorticoids References: Guyton 1986, Berne et al.1998 & Paulson et al. 1996, Thase & Howland 1995, Musselmann et al. 1998 Hypothalamus Corticotropin Releasing Factor (CRF) Catacholamines Vasoconstrictive activity Facilitate Sustain myocardial performance Fig. 3: Cardiovascular activity of the glucocorticoids Pituitary Adrenocorticotropic Hormone (ACTH) Adrenal Cortex Glucocorticoid production ↓ vasodilator prostaglandins References: Guyton (1986), Berne et al. (1998) & Paulson et al. (1996), Thase & Howland (1995) 57
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To the Heart of the Matter - examin
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Contents To the Heart of the Matter
Page 5 and 6: 1. Introduction To the Heart of the
Page 7 and 8: To the Heart of the Matter medicine
Page 9 and 10: 2. The Context of Medicine in an Hi
Page 11 and 12: To the Heart of the Matter biomedic
Page 13 and 14: 2.3. The Conceptual Context of West
Page 15 and 16: 2.3.2. Defining the Empirical Under
Page 17 and 18: To the Heart of the Matter accordan
Page 19 and 20: To the Heart of the Matter That th
Page 21 and 22: To the Heart of the Matter The acti
Page 23 and 24: To the Heart of the Matter anxiogen
Page 25 and 26: To the Heart of the Matter It would
Page 27 and 28: To the Heart of the Matter vasocons
Page 29 and 30: 4.3. Cardiovascular Pathogenesis ~
Page 31 and 32: To the Heart of the Matter fatality
Page 33 and 34: To the Heart of the Matter The hear
Page 35 and 36: To the Heart of the Matter Eysenck
Page 37 and 38: 5.2.1. Influential Development in P
Page 39 and 40: To the Heart of the Matter citation
Page 41 and 42: Selenicerus grandiflorus (L.) Britt
Page 43 and 44: To the Heart of the Matter there ar
Page 45 and 46: To the Heart of the Matter 6. Asses
Page 47 and 48: To the Heart of the Matter or psych
Page 49 and 50: To the Heart of the Matter in the P
Page 51 and 52: 7. Conclusion To the Heart of the M
Page 53 and 54: Appendix I Extrinsic Autonomic Cont
Page 55: Appendix III Cardiovascular Control
Page 59 and 60: Appendix VII Juxtaglomerular appara
Page 61 and 62: Appendix IX To the Heart of the Mat
Page 63 and 64: Appendix XI Attributes and Correspo
Page 65 and 66: Appendix XIII Traditional and Empir
Page 67 and 68: Appendix XIII cont’d Traditional
Page 69 and 70: References To the Heart of the Matt
Page 71 and 72: To the Heart of the Matter HOLMES,
Page 73 and 74: To the Heart of the Matter SCHEIER,
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