Millistak+HC AppGd_textC.qxd - Millipore

Steam-in-Place Sterilization
While working with steam, all
necessary precautions should be
taken to prevent injury. All hot lines
and housings should be labeled and,
if possible, insulated. Proper signage
should be displayed, warning of any
hot surfaces. All persons involved in
the steaming operation should be
outfitted with appropriate personal
protective equipment.
Before starting the steam-in-place
(SIP) procedure, check for the following:
• The filter housing is installed and
the correct product filter is in place.
• Filter retainer plates are in place
above and below the Millistak+ HC
cartridges.
Millistak+ HC Filters Application Guide
• The product filter is dry.
Note: If the assembled stack has
been tested for leaks, as described
above, a blow-down to remove
residual water from within the
filter media is required. This is
accomplished by applying a 5 psi
forward pressure to the feed side
of the housing to force the water
through for approximately 30
minutes, or until the water flow
is observed to have stopped.
• All valves are closed. Silicone
tubing is attached to the bleed
valves and directed to a
condensate drain.
The manual operations described in
this procedure should be performed
in the given sequence. For automatic
SIP procedures, refer to the Principles
of Steam-In-Place Technical Brief
(Lit. No. ET011EN00).
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