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Appendix A. Final Report Amendment. FINAL REPORT AMENDMENT NO. 1 PTRL West <strong>Project</strong> No. 1977W Report 2 Page 40 A. Title: Method Validation of an Analytical Method for the Determination of MCW-2 and its Metabolites in Plant Matrices B. Report Modifications: Pages were updated to include the following changes/additions: The synonym for butene sulfonic acid was changed from MAN-2 to M-3627 (pages 1, 12, 17and 21) The name of M-3625 was changed to thiazole sulfonic acid sodium salt and M- 3627 to butene sulfonic acid sodium salt (pages 11, 12 and 19) when referring to the reference substances in the solid form. An additional table and text was added on page 14. The LOD was changed to 0.45 ng/mL for thiazole sulfonic acid and butene sulfonic acid The residue calculations were updated to account for spiking with butene sulfonic acid sodium salt and thiazole sulfonic acid sodium salt, while analyzing for butene sulfonic acid and thiazole sulfonic acid by LC-MS/MS. This update allows for correct calculation of the percent recovery and will allow for quantitation of butene sulfonic acid and thiazole sulfonic acid residues as ppm free acids (pages 20 and 22, Appendix C). All the tables and text (pages 21 to 24) were updated with the recalculated percent recoveries. The representative calibration curve figures were updated (pages 19 and 28). The spreadsheets for butene sulfonic acid and thiazole sulfonic acid were updated (Appendix C) C. Reason(s): Corrects the residue method calculation for fortification with sodium salts but residue analysis as free acids for butene sulfonic acid (M-3627) and thiazole sulfonic acid (M-3625).
D. Impact on Study: Prepared By: No adverse impact on the study is expected. Study Director Amended Study Completion Date PTRL West <strong>Project</strong> No. 1977W Report 2 Page 41
Page 1 and 2: TITLE Method Validation of an Analy
Page 3 and 4: PTRL West Project No. 1977W Report
Page 5 and 6: STUDY PERSONNEL PTRL West Project N
Page 13 and 14: MATERIALS AND METHODS Reference Sub
Page 17 and 18: 3. Add 50 ml of ACN:HPLC water (1:1
Page 19 and 20: Injection Volume: 20 µL Solvent Sy
Page 21 and 22: Retention Time: Butene sulfonic aci
Page 39: PTRL West Project No. 1977W Report

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