Full Journal - Journal of Cell and Molecular Biology - Haliç Üniversitesi

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52 Gül Özcan Ar›can and Nazl› Nazmiye Soy pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy. Drugs. 45: 788- 856, 1993. Hill BT and Whelan RDH. A comparison of the lethal and kinetic effects of doxorubicin and 4’-epidoxorubicin in vitro. Tumori. 68: 29-37, 1982. Jaffrezou JP, Levade T, Bettaieb A, Andrieu N, Bezombes C, Maestre N, Vermeersch S, Rousse A and Laurent G. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J. 15: 2417-2424, 1996. Keprtova J, Vyhnakova M, Minarova E and Kleinwachter V. Effects of daunomycin and its macromolecular analog daunophilin on the proliferation of mammalian cells. Neoplasma. 40(3): 161-165, 1993. Lee YC, Byfield JE, Bennet LR and Chan PYM. X-ray repair replication in L1210 leukemia cells. Cancer Research. 34: 2624-2633, 1974. Lollini PL, De Giovanni C and Del Re B. Myogenic differentiation of human rhabdomyosarcoma cells induced in vitro by antineoplastic drugs. Cancer Res. 49: 3631-3636, 1989. Ling YH, Priebe W and Perez Solar R. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug resistant cells. Cancer Res. 53: 1845-1852, 1993. Mansilla S, Pina B and Portugal J. Daunorubicin- induced variations in gene transcription; commitment to proliferation arrest, senesence and apoptosis. J. Biochem. 372:703-711, 2003. Masquelier M and Vitols S. Drastic effect of cell density on the cytotoxicity of daunorubicin and cytosine arabinoside. Biochemical Pharmacology. 67(9): 1639- 1646, 2004. Mc Daid HM and Johnston PG. Synergistic interaction between paclitaxel and 8-chloro-adenosine 3’,5’monophosphate in human ovarian carcinoma cell lines. Clin Cancer Res. 5(1): 215-220, 1999. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods. 65: 55-63, 1983. Mouridsen HT, Alfthan C, Bastholt L, Bergh J and Dalmark M. Current status of epirubicin (farmorubicin) in the treatment of solid tumours. Acta Oncologica. 29: 257- 285, 1990. Piagram WJ, Fuller W and Hamilton LD. Stereochemistry of intercalation: interaction of daunomycin with DNA. Nature New Biology. 235: 17-19, 1972. Plosker GL and Faulds D. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cancer chemotherapy. Drugs. 45: 788-856, 1993. Ralph LD, Thomson AH, Dobbs NA and Twelves C. A population model of epirubicin pharmacokinetics and application to dosage guidelines. Cancer Chemother Pharmacol. 52: 34-40, 2003. Robert J and Gianni L. Pharmacocinetics and metabolism of anthracyclines. Cancer Surv. 17: 219-252, 1993. Rocchi P, Ferreri AM and Simone G. Epirubicin-induced differentiation of human neuroblastoma cells in vitro. Anticancer Research. 7: 247-250, 1987. Skladanowski A and Konopa J. Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells. Biochem Pharmacol. 46 (3): 375-82, 1993. Spadari S, Pedrali- Noy G, Focher F, Montecucco A and Bordoni T. DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Research. 6: 935-940, 1986. Topçul MR, Ar›can Özcan G, Erensoy N and Özalpan A. Effect of epirubicin and tamoxifen on labelling index in FM3A cells. J Cell and Mol Biol. 2: 81-85, 2002. Zhang W, Zalcberg JR and Cosolo W. Interaction of epirubicin with other cytotoxic and anti-emetic drugs. Anticancer Drugs. 3(6): 593-597, 1992.
Introduction Journal of Cell and Molecular Biology 4: 53-58, 2005. Haliç University, Printed in Turkey. Effect of MMP-1 polymorphism on early term osseointegrated dental implant failure: A pilot study Volkan Ar›san*, Cüneyt Karabuda and Tayfun Özdemir *Istanbul University, Faculty of Dentistry, Department of Oral Implantology, Capa-Istanbul-TURKEY (* author of correspondence) Abstract Osseointegrated dental implants are widely used for replacing missing teeth. Despite of reported high success rates, failures during healing phase of dental implants are still remarkable. Even under strictly controlled cases, sometimes bone tissue does not attach to titanium implant body or the implant body is lost by acute inflammatory reaction during healing phase. Genetic polymorphism may be a promoting factor for this phenomenon. Intravenous blood samples are taken from 11 patients who lost at least one dental implant during healing phase. Genomic DNA was amplified by polymer chain reaction (PCR) and analyzed by endonucleases. Within the limited results of this study it may be concluded that MMP-1 gene polymorphism may be associated with failure during healing time of Osseointegrated dental implants KKeeyy wwoorrddss:: polymorphism, implant failure, matrix metalloproteinases, early implant loss. MMP-1 Polimorfizminin Erken Dönem Osseointegre ‹mplant Baflar›s›zl›¤›na Etkisi: Pilot Çal›flma Özet Osseointegre difl implantlar› difl eksikli¤ini giderilmesinde yayg›n olarak kullan›lmaktad›r. Bildirililen yüksek baflar› oranlar›na ra¤men, iyileflme dönemindeki kay›plar halen sorgulanmaktad›r. S›k› kontrol alt›ndaki vakalarda bile kimi zaman konak kemik dokusu implant yüzeyine yap›flmamakta veya akut inflemasyon sonucu implant kaybedilmektedir. Genetik polimorfizmin bunda rolü olabilir. ‹yileflme döneminde en az 1 implant kaybeden 11 hastadan intavenöz kan örnekleri al›nm›flt›r. Genomik DNA polimeraz zincir reaksiyonu (PCR) ile büyütülmüfl ve endonükleaz enzimleri ile analiz edilmifltir. Bu çal›flma s›n›rlar›nda MMP-1 gen poliformizminin osseointegre difl imlantlar›n›n iyileflme dönemindeki kay›plar ile iliflkili olabilece¤i düflünülebilir. AAnnaahhttaarr SSöözzccüükklleerr:: Polimorfizm, implant baflar›s›zl›¤›, matriks metaloproteinaz, erken implant kayb› Osseointegration is called as direct contact of vital bone to a load bearing titanium implant surface. Branemark et al., (1977) demonstrated the utilization of osseointegrated titanium dental implants for the rehabilitation of edentulous patients. The results were quite satisfactory for the patients. Afterwards, various kinds of applications had published and dental implant therapy has become a standard therapy for replacing missing teeth. In this treatment protocol, implants are inserted 53
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