Download the full report (116 p.) - KCE
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32 Multislice CT in Coronary Heart Disease <strong>KCE</strong> Reports 82<br />
Table 7: Diagnostic performance of 2007/2008 diagnostic studies on 64-SCT in native coronary arteries and meta-analyses.<br />
n<br />
CAD<br />
SENSITIVITY<br />
prevalence<br />
ABDULLA's SR<br />
SPECIFICITY pos LR neg LR<br />
Abdulla 66 1251 57,50% 97,5 (96-99)<br />
64-SCT<br />
91 (87,5-94) 7,3 (4,4-12,2) 0,05 (0,03-0,08)<br />
Hausleiter 77 114 42% 99 (94-99) 75 (67-82) - -<br />
Herzog 40 55 35% 100 (85,4-100) 83,3 (67,1-93,6) 5,5 (2,8-11,2) 0,03 (0,00-0,47)<br />
Meijboom prevalence 83 254 50% 98 (94-100) 86 (78-91) 7,00 0,02<br />
Meijboom gender<br />
51% F 100 (93-100) 75 (62-85) 3,9 (2,5-6,0) 0,01 (0,00-0,17)<br />
69 402<br />
68% M 99 (96-100) 90 (81-95) 9,8 (5,3-18,2) 0,01 (0,00-0,05)<br />
Shabestari 70 143 76% 96 (91-99) 67 (47-83) 2,2 (1,5-3,3) 0,07 (0,02-0,18)<br />
Shapiro 78 37 78% 97 (80-100) 63 (20-93) 2,6 (1,1-6,3) 0,06 (0,01-0,41)<br />
DUAL-SOURCE 64-SCT<br />
Alkadhi 33 150 39,3 96,6 (87,2-99,9) 86,8 (77,2-93,9) 7,3 (4,3-12,4) 0,04 (0,01-0,15)<br />
Leber 68 90 24% 95 (76-99) 90 (80-95) 7,3 (3,9-13,5) 0,06 (0,01-0,37)<br />
Ropers 76 100 41% 98 (88-100) 81 (69-89) 5,1 (3,0-8,8) 0,03 (0,00-0,21)<br />
Weustink 71 100 77% 99 (92-100) 87 (65-97) 7,6 (2,6-21,7) 0,02 (0,00-0,11)<br />
<strong>KCE</strong> META-ANALYSES<br />
2007/2008 studies 1077 56.5% 98 (96,6-99,0) 82,3 (78,5-85,7) 5,0 (3,5-7,4) 0,03 (0,02-0,06)<br />
DUAL-SOURCE 64-SCT 440 45.2% 97,5 (94,2-99,2) 85,5 (80,4-89,7) 6,5 (4,8-8,9) 0,03 (0,01-0,08)<br />
CAD prevalence referring to <strong>the</strong> presence of at least one ≥50% stenosis on CCA. Sensitivity and specificity data as <strong>report</strong>ed in original papers. Results from meta-analyses are<br />
shaded grey. In LR-calculations and <strong>KCE</strong> meta-analyses, inconclusive MSCT results are counted as false positives which made results slightly different as compared to original<br />
data in 68 and 78. Hausleiter and Meijboom-prevalence data not incorporated in meta-analysis. Pooled estimates form Abdulla 66 are shown for comparison. Standard “64-SCT”<br />
refers to studies with <strong>the</strong> original single source 64-SCT devices. “<strong>KCE</strong>-<strong>report</strong>” refers to <strong>the</strong> meta-analyses discussed in this <strong>report</strong>, obtained by pooling (1) all recent trials and<br />
(2) in a second calculation <strong>the</strong> dual-source 64-SCT trials separately (cf. text and appendix).
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