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46 Interventions in Alzheimer’s Disease KCE Reports 111
EMBASE January 2004 – September 2008 52
OVID ECONLIT January 2004 – September 2008 2
Total 131
Total Research questions 1 and 2 750
Duplicates within Research question 1 152
Duplicates within Research question 2 22
Duplicates between Research questions 1 and 2 22
Unique citations for Research questions 1 and 2 554
5.1.2 Selection criteria
5.1.2.1 HTA reports
Only the most recent HTAs including a qualitative systematic review of the economic
literature related to the above questions of interest were retained.
5.1.2.2 Economic evaluations and reviews of economic evaluations
All retrieved references were assessed against pre-defined selection criteria, in terms of
population, intervention, and design (Table 8) in a two-step procedure: initial
assessment of the title, abstract, and keywords, followed by a full-text assessment of the
selected references. When no abstract was available and the citation was unclear or
ambiguous, consideration of the citation was directly made on the basis of full-text
assessment. Reference lists of the selected studies were checked for additional relevant
citations. The selected full economic evaluations, i.e. the studies comparing at least two
alternative treatments in terms of costs and outcomes (see classification in appendix),
were then summarised in in-house data extraction forms.
Table 8: Economic evaluations selection criteria
Inclusion criteria Exclusion criteria
Pharmacologic and non-pharmacologic treatment in AD patients
Population Patients suffering from AD Other patient groups
Intervention Pharmacologic and non-pharmacologic Other interventions, diagnostic
treatment
tools
Design Full economic evaluations (primary or
secondary studies)
Partial economic evaluations, etc
Non-pharmacologic treatment in dementia patients
Population Patients suffering from dementia Other patient groups
Intervention Non-pharmacologic treatment Other interventions, diagnostic
tools
Design Full economic evaluations (primary or
secondary studies)
5.1.3 Selection process
5.1.3.1 HTA reports
Partial economic evaluations, etc
Of the 80 HTA citations identified, 5 HTA reports including a systematic review of the
economic literature on Alzheimer disease or dementia treatments fulfilled the selection
criteria. 1, 21, 72, 88, 89 Of those, the two eldest HTA reports 88, 89 were discarded since both
21, 72
reports were updated and included in most recent HTAs’ reviews.