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V(D)J recombination and its defects

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EBF, LIG4 <strong>and</strong> RAG1 gene expression in human<br />

CD34 + lin – <strong>and</strong> precursor B-cell subsets<br />

3<br />

2<br />

1<br />

0<br />

-1<br />

-2<br />

12<br />

n=408<br />

CD34<br />

pro-B<br />

pre-B-I<br />

pre-B-II large<br />

pre-B-II small<br />

immature-B<br />

+ lin –<br />

M.C. van Zelm, et al. J Immunol. 2005; 175: 5912-5922.<br />

EBF<br />

LIG4<br />

RAG1

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