V(D)J recombination and its defects
V(D)J recombination and its defects
V(D)J recombination and its defects
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V(D)J <strong>recombination</strong> in detail<br />
1<br />
2<br />
Vκ Vκ<br />
Jκ<br />
coding joint<br />
hairpin<br />
coding ends<br />
opened<br />
hairpins<br />
TdT activity<br />
DNA-PKcs, Ku70/Ku80<br />
<strong>and</strong> Artemis<br />
hairpin cleavage<br />
RAG1/RAG2 complex binds<br />
to RSS DNA cleavage<br />
blunt<br />
signal ends<br />
ligation by<br />
DNA ligase IV, XRCC4 <strong>and</strong> XLF<br />
signal joint
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