V(D)J recombination and its defects
V(D)J recombination and its defects
V(D)J recombination and its defects
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T – B – NK + SCID patients without<br />
RAG gene mutations<br />
- A number of these patients are sensitive to ionizing<br />
radiation<br />
- Causative defect in DNA double str<strong>and</strong> break (dsb)<br />
repair via non-homologous end joining (NHEJ)