V(D)J recombination and its defects

More documents

Recommendations

Info

V(D)J recombination in detail 1 2 Vκ Vκ Jκ coding joint hairpin coding ends opened hairpins TdT activity DNA-PKcs, Ku70/Ku80 and Artemis hairpin cleavage RAG1/RAG2 complex binds to RSS DNA cleavage blunt signal ends ligation by DNA ligase IV, XRCC4 and XLF signal joint
Clonogenic survival assay of fibroblasts after ionizing radiation (Artemis 1,2,3) % survival 100 10 1 0.1 0.01 0 1 2 3 4 5 6 Dose of X-rays (Gy) FN1 (wild type) NBS-1LBI Artemis-1 Artemis-2 Artemis-3.1 Artemis-3.2
Page 1 and 2: ESID Prague meeting, 14-15 May 2007
Page 3 and 4: V(D)J recombination of the IGH gene
Page 5 and 6: V D IgH IgH V D J J V C C V J J IgL
Page 7 and 8: IGH gene rearrangements quantified
Page 9 and 10: Gene expression profiling of human
Page 11 and 12: EBF, LIG4 and RAG1 gene expression
Page 13 and 14: Cell 2006;124:260-262.
Page 15 and 16: Outline - V(D)J recombination and i
Page 17 and 18: T-B-NK+ SCID is caused by defect in
Page 19 and 20: Flowcytometric analysis of precurso
Page 21 and 22: CyIgµ/SmIgM/CD19 on bone marrow of
Page 23: T - B - NK + SCID patients without
Page 27 and 28: Signal and coding joint formation i
Page 29 and 30: Composition of the precursor B-cell
Page 31: Composition of junction regions DH
Page 34 and 35: Case report of T-B-NK+ SCID - Girl
Page 36 and 37: Clonogenic survival assay of fibrob
Page 38 and 39: Composition of coding joints of pat
Page 40 and 41: RS-SCID caused by a deletion of thr
Page 42 and 43: Conclusions - V(D)J recombination d
Page 44 and 45: Acknowlegdements Dept. of Cell biol
Page 46 and 47: Differences in outcome of SCT of B-
Page 48 and 49: “Lack of Space hypothesis” No B
Page 50 and 51: Short tandem repeat (STR) analysis
Page 52 and 53: Second SCT - Artemis-deficient SCID
Page 54 and 55: Post-SCT2 precursor B-cells of dono
Page 56: Acknowlegdements Dept. of Immunolog

V(D)J recombination and its defects

Create successful ePaper yourself

Delete template?

Save as template?