V(D)J recombination and its defects
V(D)J recombination and its defects
V(D)J recombination and its defects
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V(D)J <strong>recombination</strong><br />
- Initiation by RAG1 <strong>and</strong> RAG2 is lymphoid specific<br />
- Hairpinopening, endprocessing <strong>and</strong> ligation by non<br />
homologous end joining (NHEJ) pathway for DNA ds<br />
break repair (Ku70, Ku80, DNA-PKcs, LIG4, XRCC4, XLF-Cernunnos)