V(D)J recombination and its defects

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“Lack of Space hypothesis” No B-cell engraftment post-SCT in B-negative SCID patients because of lack of physical space in bone marrow due to the presence of a relatively high frequency of early precursor B- cells (pro-B <strong>and</strong> pre-B-I), which are not eradicated with mild pre-SCT conditioning Van der Burg et al. Hematol 2006; 91:1705-9
Analysis of precursor B-cell compartment at diagnosis <strong>and</strong> post-SCT Average
Page 1 and 2: ESID Prague meeting, 14-15 May 2007
Page 3 and 4: V(D)J recombination of the IGH gene
Page 5 and 6: V D IgH IgH V D J J V C C V J J IgL
Page 7 and 8: IGH gene rearrangements quantified
Page 9 and 10: Gene expression profiling of human
Page 11 and 12: EBF, LIG4 and RAG1 gene expression
Page 13 and 14: Cell 2006;124:260-262.
Page 15 and 16: Outline - V(D)J recombination and i
Page 17 and 18: T-B-NK+ SCID is caused by defect in
Page 19 and 20: Flowcytometric analysis of precurso
Page 21 and 22: CyIgµ/SmIgM/CD19 on bone marrow of
Page 23 and 24: T - B - NK + SCID patients without
Page 25 and 26: Clonogenic survival assay of fibrob
Page 27 and 28: Signal and coding joint formation i
Page 29 and 30: Composition of the precursor B-cell
Page 31: Composition of junction regions DH
Page 34 and 35: Case report of T-B-NK+ SCID - Girl
Page 36 and 37: Clonogenic survival assay of fibrob
Page 38 and 39: Composition of coding joints of pat
Page 40 and 41: RS-SCID caused by a deletion of thr
Page 42 and 43: Conclusions - V(D)J recombination d
Page 44 and 45: Acknowlegdements Dept. of Cell biol
Page 46 and 47: Differences in outcome of SCT of B-
Page 50 and 51: Short tandem repeat (STR) analysis
Page 52 and 53: Second SCT - Artemis-deficient SCID
Page 54 and 55: Post-SCT2 precursor B-cells of dono
Page 56: Acknowlegdements Dept. of Immunolog

V(D)J recombination and its defects

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