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production of animal proteins by cell systems - New Harvest

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equired do not much extend beyond those for single-<strong>cell</strong>ed (eukaryotic) microorganisms. This is<br />

largely due to the considerable shear-stress resistance <strong>of</strong> these <strong>cell</strong>s. Besides shear-stress<br />

resistance, two other major factors in the scale-up <strong>of</strong> the growth <strong>of</strong> <strong>animal</strong> <strong>cell</strong>s is their<br />

dependence on (i) specific growth factors and (ii) a solid support.<br />

Literature<br />

1. Giesecke, D., S. Gaebler, and W. Tiemeyer, Purine Availability and Metabolism in Dogs Fed<br />

Single-Cell Protein or Rna. Journal <strong>of</strong> Nutrition, 1982. 112(10): p. 1822-1826.<br />

2. Colla, L.M., et al., Production <strong>of</strong> biomass and nutraceutical compounds <strong>by</strong> Spirulina platensis<br />

under different temperature and nitrogen regimes. Bioresour Technol, 2007. 98(7): p. 1489-<br />

93.<br />

3. Sikkeland, L.I., et al., Complement activation and cytokine response <strong>by</strong> BioProtein, a bacterial<br />

single <strong>cell</strong> protein. Clin Exp Immunol, 2007. 148(1): p. 146-52.<br />

4. Berg, J.J., Tymoczko, J.L., Stryer, L., Biochemistry. Sixth Edition ed. 2006, <strong>New</strong> York: W.H.<br />

Freeman and Company.<br />

5. Woodham, A.A. and E.M. Clarke, Nutritive value <strong>of</strong> mixed <strong>proteins</strong>. 2. As determined <strong>by</strong> net<br />

protein utilization and protein efficiency ratio tests. Br J Nutr, 1977. 37(3): p. 309-19.<br />

6. Moon N.J., H.E.G., Glatz B.A., Conversion <strong>of</strong> cheese whey and whey permeate to oil and<br />

single-<strong>cell</strong> protein. Dairy Science, 1978. 61: p. 1537-1547.<br />

7. Evenblij, M., Veroudering en DNA schade. Mediator, 2009. 20(3): p. 8-9.<br />

8. Garinis, G.A., et al., Persistent transcription-blocking DNA lesions trigger somatic growth<br />

attenuation associated with longevity. Nature Cell Biology, 2009. 11(5): p. 604-U370.<br />

9. Gudbrandsen, O.A., et al., Dietary single <strong>cell</strong> protein reduces fatty liver in obese Zucker rats.<br />

Br J Nutr, 2008. 100(4): p. 776-85.<br />

10. Chan, L.C., P.F. Greenfield, and S. Reid, Optimising fed-batch <strong>production</strong> <strong>of</strong> recombinant<br />

<strong>proteins</strong> using the baculovirus expression vector system. Biotechnol Bioeng, 1998. 59(2): p.<br />

178-88.<br />

*essential amino acids: Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine,<br />

Tryptophan, Valine<br />

*semi-essential (in young children): Tyrosine, Cysteïne, Histidine, Arginine<br />

54

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