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The differential diagnosis of hypernatraemia in children, with ...

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<strong>The</strong> Diagnosis <strong>of</strong> Salt Poison<strong>in</strong>g Lead<strong>in</strong>g to Hypematraemia <strong>in</strong> Children – September 2009<br />

gave him large glasses <strong>of</strong> sodium bicarbonate…. he was forced to dr<strong>in</strong>k it and was<br />

told he would be hit <strong>with</strong> a belt if he didn’t…. <strong>in</strong> an attempt to <strong>in</strong>duce vomit<strong>in</strong>g the<br />

babysitter put her foot on the child’s stomach.”<br />

<strong>The</strong> babysitter pleaded guilty to negligent contribution to the death <strong>of</strong> a m<strong>in</strong>or. Both peer<br />

reviewers agreed beyond reasonable doubt <strong>with</strong> the authors’ conclusions.<br />

Evidence statement<br />

<strong>The</strong>re is a s<strong>in</strong>gle, credible case report <strong>of</strong> deliberate and forcible adm<strong>in</strong>istration <strong>of</strong><br />

sodium bicarbonate by a babysitter caus<strong>in</strong>g the death <strong>of</strong> the child [Grade C].<br />

4.4.3 Children prevented from dr<strong>in</strong>k<strong>in</strong>g, “thirst<strong>in</strong>g”<br />

225, 237-239<br />

<strong>The</strong>re have been several reports <strong>of</strong> <strong>hypernatraemia</strong> secondary to water deprivation<br />

<strong>in</strong>volv<strong>in</strong>g 6 <strong>children</strong>, where there was not thought to be excessive salt adm<strong>in</strong>istration. All<br />

three <strong>children</strong> <strong>in</strong> the first case series had good evidence <strong>of</strong> moderate to severe dehydration<br />

at the time <strong>of</strong> admission.<br />

<strong>The</strong> first case report, from San Francisco, was <strong>of</strong> three <strong>children</strong> admitted <strong>with</strong> <strong>hypernatraemia</strong><br />

<strong>in</strong> 1968. 237 <strong>The</strong> first child aged 2½ years had a serum sodium <strong>of</strong> 194.5 mEq/L on admission<br />

<strong>with</strong> a 3 day history <strong>of</strong> vomit<strong>in</strong>g. He had been adopted at 5 months, had developmental<br />

delay and had lost weight 2 to 3 months before admission ‘when his parents attempted<br />

to teach him to eat vegetables. Subsequently, he rega<strong>in</strong>ed the weight on his usual diet.<br />

His father emphasised that his appetite and <strong>in</strong>take were usually enormous.’ He had<br />

ecchymoses on his cheeks and knees. ‘Dur<strong>in</strong>g his hospital course, it became apparent the<br />

patient had been periodically thirsted by his mother while his father was away from home.’<br />

He subsequently demonstrated catch up growth and development. Both peer reviewers<br />

agreed on the balance <strong>of</strong> probability <strong>with</strong> the authors’ conclusions that this was due to<br />

the actions <strong>of</strong> a psychiatrically disturbed mother, <strong>with</strong> one po<strong>in</strong>t<strong>in</strong>g out that the additional<br />

adm<strong>in</strong>istration <strong>of</strong> salt could not be excluded as a contributory cause.<br />

<strong>The</strong> second child, a 3¾ year old, was admitted <strong>with</strong> a 3-day history <strong>of</strong> progressive loss <strong>of</strong><br />

appetite, <strong>with</strong> <strong>in</strong>creas<strong>in</strong>g irritability and <strong>in</strong>ability to walk or stand. He had had four loose<br />

bowel motions a week earlier and weight loss over 3 months. His <strong>in</strong>itial sodium was 201<br />

mEq/L. At the time <strong>of</strong> admission he had multiple bruises <strong>in</strong>clud<strong>in</strong>g ‘a 2 x 2 cm bruise on<br />

the left cheek, a 3 x 4 cm bruise on the right buttock, and numerous smaller bruises over<br />

the lower extremities.’ ‘A baby sitter and the maternal grandfather each made unsolicited<br />

telephone calls to say that the patient’s mother had <strong>in</strong>structed them on numerous occasions<br />

58

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