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Sensory & Motor Grip Strength Meter for Evaluation of Muscular Strength Grip Strength Meter The grip strength meter allows the study of neuromuscular functions in rodents by determining the maximum force displayed by an animal. This test is included in the Functional Observational Battery (FOB) to screen for neurobehavioral toxicity. In this context, changes in grip strength are interpreted as evidence of motor neurotoxicity. The grip strength meter is positioned horizontally and the subjects are held by the tail and lowered towards the apparatus. The animals are allowed to grasp the metal grid or T-bar and are then pulled backwards in the horizontal plane. The force applied to the grid or to the bar just before it loses grip is recorded as the peak tension. This force can be measured in kilograms, grams, pounds or Newtons. Data output is carried out through RS-232, printer, or chart recorder. Depending on the grid type used, grip strength can be measured from the front or hind paws. Grip Test Accessories Specifications Dimensions of 2 Grid System 750 (W) x 180 (D) x 200 (H) mm Sensor Capacity 0-2 kG (20N) Sampling Speed 1000 Hz Measurement Range 0 to 2000 grams Bar for Rat (for front or rear paws) Bar for Mouse (for front or rear paws) Grid for Rats (for four paws) Grid for Mouse (for front paws & four paws) Resolution Accuracy Material Composition 0.1 gram 0.2 % of full scale Stainless steel (Grid) Power Supply 110 V/220 V Dimensions of Single System 400 (W) x 180 (D) x 200 (H) mm Key Features ➤ Stand alone system, PC optional, not required ➤ Fits to rats and mice with a simple change of grip accessories ➤ Multi-units display: kgs, grams, lbs., Newtons ➤ New and unique internal computations allows direct reading of average value, standard deviation and variability for subjects and up to 100 animals Parameters Measured ➤ Maximum force developed by the front and hind paws Components Included ➤ Display unit with RS-232 connection for PC ➤ Metal stand ➤ Grid or bar (one or two grids/bar) ➤ Instruction manual ➤ 1 year warranty Options ➤ RS-232 cable ➤ RSIC software ➤ Additional grid/bar ➤ Statistical impact printer with cable Order # Model Product BH2 76-0483 BSBIOGS3 Grip Strength Test Complete with 1 Accessory, 110 or 220 Volts BH2 76-0484 BSBIORSIC Data Acquisition RSIC Software Windows ® XP (Dongle and CD) BH2 76-0485 BSBIOAGRS232 RS-232 Cable BH2 76-0479 BSBIOGRIPBR Bar for Rats (Front Paws) BH2 76-0480 BSBIOGRIPBS Bar for Mice (Front or Rear Paws) BH2 76-0481 BSBIOGRIPGR Grid for Rats (Front or Four Paws) BH2 76-0482 BSBIOGRIPGS Grid for Mice (Front & Four paws) Citations Dudra-Jastrzebska et al. (2009) Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: An isobolographic analysis. Eur. J. Pharmacol. 605(1-3): 87-94. (mouse, Poland, UK) Dupuis L et al. (2009) Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons. PLoS ONE 4(4):e5390. (mouse, France) Kozinska J et al (2009) Spironolactone potentiates the protective action of some selected antiepileptic drugs against maximal electroshock-induced seizures in mice. Annales UMCS, Pharmacia. 22(1):123- 134. (mouse, Poland) Lambertsen KL et al. (2009) Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor. J. Neurosci. 29(5):1319-1330. (BIO-GT3, mouse, Denmark, Sweden). Luszczki JJ et al. (2009) N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model Neurosci. Res. 64(3):267-272. (mouse, Poland, Armenia) Akhtar M et al. (2008) Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats. Human & Experimental Toxicology. 27(10):761-767. (rat, India) Harvard Apparatus • phone 508.893.8999 • toll free U.S. 800.272.2775 • fax 508.429.5732 • www.harvardapparatus.com Panlab | Harvard Apparatus • Spain +34934190709 • International +34834750697 • fax +34934750699 • www.panlab.com 23
Sensory & Motor Grip-Strength Meter Peak Preamplifier Both the Grip Strength Meter for Rats and the model for Mice are used with this Peak Amplifier. It automatically discriminates whether the grip force is generated by the rat and mouse transducer and expresses them in grams and in decimal of grams respectively. The data supplied by the peak amplifier is available in digital and analog form. The waveform of the pull can be externally recorded, for example via a channel recorder or the signal may be taken to a data acquisition system. Grip-Strength Meter is Supplied Complete with the Following Components • Peak Amplifier, incorporating a digital display • Force Transducer Suitable for Either Rats or Mice • Trapezes for Either Rats or Mice, T-shaped bar for Either Rats or Mice • Perspex Plate with 10 mm diameter upright • Open-Side Boss Head • Table Clamp • Mains Cable • Set of 2 fuses for either 115 V or 230 V operation • Instruction Manual Grip-Strength Meter This system measures the force that is required to make a mouse or rat release its grip. It is ideal to measure the effects of drugs, toxins, muscle relaxants, disease, aging or neural damage on muscle strength. The rat or mouse is placed over a Perspex plate, in front of a grasping bar, either T-shaped or trapeze-shaped. Rodents instinctively grab anything they can to try to stop this involuntary backward movement. The will continue to grip the trapeze until the pulling force overcomes their grip strength. After the animal loses its grip, the peak preamplifier automatically stores the peak pull force and shows it on a liquid crystal display. The sensor mechanism is a T-shaped or trapeze-shaped bar whose height is adjustable. The bar is fitted to a force transducer connected to the Peak Amplifier. The Mouse unit is similar to the rat model except the grasping trapeze is proportionately sized for mice and the transducer sensitivity is adjusted to measure the grip strength of mice. A complete system is comprised of the follow components: 1. A base plate of black sand-blasted Perspex, complete with upright and open-side boss-head 2. A grasping-bar (a grasping trapeze is also supplied) 3. A force transducer of adjustable height, provided with connection cable and connector to the peak amplifier 4. A peak amplifier Order # Model Product BH2 72-6713 47105/115 V Grip-Strength Meter for Rats, 115 V/230 V BH2 72-6715 47106/115 V Grip-Strength Meter for Mice, 115 V/230 V REPLACEMENT PARTS BH2 72-6717 47105-002 Force Transducer Assembly for Rat BH2 72-6718 47105-003 Force Transducer Assembly for Mouse BH2 72-6719 47105-004 Pespex Plate with 10 mm Diameter Upright BH2 72-6723 47105-323 Table Clamp BH2 72-6725 4003 Open-Side Boss Head 24 Harvard Apparatus • phone 508.893.8999 • toll free U.S. 800.272.2775 • fax 508.429.5732 • www.harvardapparatus.com Panlab | Harvard Apparatus • Spain +34934190709 • International +34834750697 • fax +34934750699 • www.panlab.com
Page 1 and 2: the most comprehensive line for Beh
Page 3 and 4: Table of Contents Spatial Place Pre
Page 5 and 6: Do you have a technical question? O
Page 7 and 8: Video Tracking SMART Video-Tracking
Page 9 and 10: Video Tracking Smart Junior Right t
Page 11 and 12: Locomotor Activity & Exploration Gu
Page 17 and 18: Locomotor Activity & Exploration IR
Page 19 and 20: Sensory Motor & Coordination Guide
Page 23: Sensory & Motor Rota Rod for Motor
Page 27 and 28: Sensory & Motor Rodent Activity Whe
Page 29 and 30: Sensory & Motor Small Animal Treadm
Page 31 and 32: Sensory & Motor HSE-HA Rodent Shock
Page 33 and 34: Analgesia Guide Behavioral Test Tai
Page 35 and 36: Analgesia Guide Behavioral Test Inc
Page 37 and 38: Analgesia Tail Flick Meter BH2 52-9
Page 39 and 40: Analgesia Hot-Plate for Evaluating
Page 41 and 42: Analgesia NEW Thermal Place Prefere
Page 43 and 44: Analgesia NEW Electronic Von Frey f
Page 45 and 46: Analgesia Plantar Test (Hargreaves
Page 47 and 48: Analgesia Dynamic Plantar Aesthesio
Page 49 and 50: Analgesia Plethysmometer for Evalua
Page 51 and 52: Analgesia NEW Dynamic Weight Bearin
Page 53 and 54: Analgesia Pressure Application Meas
Page 55 and 56: Learning & Memory Guide Behavioral
Page 63 and 64: Attention Guide Behavioral Test 5/9
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Learning, Memory & Attention Modula
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Anxiety Guide Anxiety is the most c
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Anxiety Guide Behavioral Test Black
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Depression Guide The term “depres
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Anxiety & Depression Elevated Plus
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Reward & Addiction Guide Behavioral
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Reward & Addiction Place Preference
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Reward & Addiction PPCWIN Software
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Food and Drink/Metabolism Guide Met
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Food and Drink/Metabolism Guide Beh
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Food & Drink/Metabolism Oxylet Syst
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Food & Drink/Metabolism Metabolism
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