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Analgesia
Tail Flick Meter for Evaluating Thermal Analgesia
Tail Flick Meter
Key Features
➤ Optimal detection due to perfect alignment of heat stimulus
and photo beam trigger
➤ Photo beams with adjustable sensitivity
➤ A light beam shows the point on which the heat source will focus
➤ Manual and remote timer and trigger
➤ Groove for correct tail placement
➤ Automatic cut-off
➤ Computer interface, SeDaCom
Parameters Measured
➤ Time latency response to thermal stimulus
Components Included
➤ Control Unit with RS-232 port to PC
➤ Stimulation unit
➤ Mouse tail adapter
➤ Holder for rat or mouse - must specify at time of order
➤ Footswitch
➤ SeDaCom software
➤ Instruction manual
➤ Calibration certificate
➤ Cables and connectors
➤ Set of spare fuses
➤ 2 year warranty
Options
➤ LE7000 Thermal printer
➤ LE7106T Tail-Temperature recorder
Tail Flick Meter
This system features radiant heat applied on the animal’s tail; when the
animal feels discomfort, it reacts by a sudden tail’s movement (tail
flick) which automatically stops the stimulation and the timer for the
measurement of the animal reaction time (period from the beginning of
the stimulation until detection of the animal’s response).
This test has proved particularly sensitive for studying the analgesic
properties of pharmacological substances. It can also be used to
evaluate basal thermal pain sensitivity or to study putative genetic
differences among control animals.
The LE7106 Tail-flick Meter consists of a stimulation unit (containing
the halogen lamp for the heat stimulus) and an electronic control unit.
The system can be used for rats and mice of different sizes. The animal
is placed in a restrainer with its tail protruding on the platform of the
stimulus unit. The animal’s tail is positioned on a slot of adjustable
width equipped with a groove that guarantees a correct placement. A
remote foot-switch controls the test start/stop allowing rapid handsfree
experiments.
A photo beam with adjustable sensitivity detects the tail flick and the
latency is automatically presented on a digital display on the control
unit. Measurements of reaction time are given with a 0.1 precision. A
cut-off time can be set to avoid tissue damage (by default: 20 s). The
groove system for the tail and the adjustment of response sensitivity
ensure optimum repeatability and reliability of results.
SeDacom software supplied with the unit can be used to automatically
record the results on a PC through a RS-232 port.
Specifications
Control Unit Dimensions
Stimulation Unit
Dimensions
Power Supply
Material Composition
350 (W) x 350 (D) x 130 (H)
400 (W) x 140 (D) x 155 (H)
110 V/220 V, 50/60Hz
Methacrylate, halogen lamp
Computer Requirements PC (Windows ® 95, 98, ME, NT, 2000, XP and Vista 32)
Maximum Number of
Stations
Certifications
Order # Model
1 per computer (multiple set-ups also available
under request)
CE compliant
Product
BH2 76-0293 LE7106 Tail Flick Analgesia Meter Including Restrainer,
Footswitch and SeDaCom Software
OPTIONS
BH2 76-0114 LE7000 Thermal Printer
BH2 76-0294 LE7106T Tail-Temperature Recorder
Citations
Gulati et al. (2009) Determination of Adrenergic and Imidazoline Receptor Involvement in
Augmentation of Morphine and Oxycodone Analgesia by Clonidine and BMS182874.
Pharmacology. 83:45-58. (rat, USA)
Puente B et al. (2009) Sigma-1 receptors regulate activity-induced spinal sensitization and
neuropathic pain after peripheral nerve injury. Pain. (Mouse, Spain). In press
Park I et al (2008) Buprederm , a New Transdermal Delivery System of Buprenorphine:
Pharmacokinetic, Efficacy and Skin Irritancy Studies. Pharm. Res. 25(5):1052-1062 (mouse, Korea)
Shamsi Meymandi M et al (2007) Intraventricular gabapentin is antinociceptive and enhances
systemic morphine antinociception in rat tail flick test. DARU. 15(4):212-217 (rat, Iran)
Parker AG et al. (2007) Antinociceptive effects of the aqueous extract of Brugmansia
suaveolens flowers in mice. Biol. Res. For Nursing. 8(3): 234-239. (Mouse, Brazil)
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