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Analgesia<br />
Rat Paw Pressure for Evaluating Mechanical Pain<br />
Rat Paw Pressure Analgesia Meter<br />
Key Features<br />
➤ Digital display<br />
➤ Pressure increasing rate adjustment<br />
➤ Data transfer software included (SeDaCom)<br />
➤ Footswitch control<br />
Parameters Measured<br />
➤ Pressure applied on the paw until the withdrawal or animal<br />
vocalizes (rats)<br />
➤ Pressure applied on the tail until withdrawn (mice)<br />
➤ Pressure applied on the paw until a flexor response of the toes<br />
(mice)<br />
Components Included<br />
➤ Control unit with RS-232 communication port to PC<br />
➤ Stimulation unit<br />
➤ Pedal switch<br />
➤ Flat and pointed tip points<br />
➤ SeDaCom software<br />
➤ Instruction manual<br />
➤ Cables and connectors<br />
➤ Set of spare fuses<br />
➤ 2 year warranty<br />
Options<br />
➤ LE7000 thermal printer<br />
Rat Paw Pressure Analgesia Meter<br />
The Randall & Selitto test is based on determination of the animal<br />
threshold response to pain induced in the paw by the application of a<br />
increasing pressure.<br />
In the LE7306 paw-pressure, a stimulation unit allows the gradual increase<br />
(at selectable rates) of the pressure applied on the animal paw. The<br />
pressure increase is achieved by a step-motor inducing the progressive<br />
advancement of a sliding support with a distal conic tip (1 mm diameter).<br />
The conic point is mounted on an extensiometric load cell, making<br />
possible the visualization on the digital display of the current force applied<br />
at each moment of the test (grams). The motor and tip units are mounted<br />
on a pivoting stand preventing any excess pressure on the animal paw.<br />
The control unit makes possible the adjustment of the force<br />
transducer, balance and reset, as well as the selection of the stepmotor<br />
current speed.<br />
A remote foot-switch controls the motor turn on/off allowing rapid<br />
hands-free experiments. An automatic system is activated once the<br />
distal extreme of the sliding support track is reached or when the<br />
pedal is released at the test ending point. Then, the motor reverse its<br />
rotation at its higher speed, sliding up the conic tip again.<br />
SeDacom software supplied with the unit can be used to automatically<br />
record the results on a PC through a RS-232 port.<br />
Specifications<br />
Power Supply<br />
Stimuli Resolution<br />
Maximum Stimuli<br />
Material Composition<br />
Computer Requirements<br />
Maximum Number<br />
of Stations<br />
Certifications<br />
Control Unit Dimensions<br />
Stimulation Unit<br />
Dimensions<br />
Order # Model<br />
110 V/220 V, 50/60Hz<br />
1 gram<br />
999 gram<br />
Methacrylate<br />
PC (Windows ® 95, 98, ME, NT, 2000, XP and Vista)<br />
1 per computer<br />
(multiple set-ups also availableunder request)<br />
CE Compliant<br />
350 (W) x 350 (D) x 130 (H) mm<br />
150 (W) x 210 (D) x 166 (H) mm<br />
Product<br />
BH2 76-0234 LE7306 Rat Paw Pressure Analgesia-Meter Including<br />
SeDaCom Software<br />
OPTIONS<br />
BH2 76-0114 LE7000 Thermal Printer<br />
Citations<br />
Fernández-Dueñas V et al (2008) Adjuvant effect of caffeine on acetylsalicylic acid antinociception:<br />
Prostaglandin E2 synthesis determination in carrageenan-induced peripheral<br />
inflammation in rat Eur. J. Pain, 12(Issue 2):157-163 (Rat, Spain)<br />
Célérier E et al. (2006) Opioid-induced hyperalgesia in a murine model of postoperative pain: role of<br />
nitric oxide generated from the inducible nitric oxide synthase. Anesthesiology 104(3): 546-555. (Pawpressure,<br />
Mice, Spain)<br />
Romero A et al (2005) Anti-exudative effects of opioid receptor agonists in a rat model of carrageenaninduced<br />
acute inflammation of the paw. Eur. J. Pharmacol. 511(2-3):207-217. (Rat, Spain)<br />
Célérier E et al. (2004) Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking<br />
the protein kinase C-gamma gene. Neuropharmacol. 46:264-272. (Tail-pressure, Mouse, Spain)<br />
Al-Naggar TB et al. (2003) Neuropharmacological activity of Nigella sativa L. extracts. J.<br />
Ethnopharmacol. 88(1): 63-68. (Rat, Spain)<br />
Gutierrez M et al. (2003) Interactions of acute morphine with chronic imipramine and fluvoxamine<br />
treatment on the antinociceptive effect in arthritic rats. 352(Issue 1): 37-40. (Rat, Spain)<br />
Martin M et al. (2003) Acute antinociceptive responses in single and combinatorial opioid receptor<br />
knockout mice: distinct mu, delta and kappa tones Eur. J. .Neurosci. 17(4):701 (Tail-pressure, Mouse, Spain)<br />
Martin M et al. (2003) Morphine withdrawal is modified in pituitary adenylate cyclase-activating<br />
polypeptide type I-receptor-deficient mice. Mol. Brain Res. 110(1):109-118. (Mouse, Spain)<br />
<strong>Harvard</strong> <strong>Apparatus</strong> • phone 508.893.8999 • toll free U.S. 800.272.2775 • fax 508.429.5732 • www.harvardapparatus.com<br />
Panlab | <strong>Harvard</strong> <strong>Apparatus</strong> • Spain +34934190709 • International +34834750697 • fax +34934750699 • www.panlab.com<br />
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