Sodium methanolate - ipcs inchem

OECD SIDS
POTASSIUM METHANOLATE
5. TOXICITY ID: 865-33-8
DATE: 28.06.2006
Test substance : other TS: Sodium methanolate
Result : GENOTOXIC EFFECTS:
- With metabolic activation: none
- Without metabolic activation: none
PRECIPITATION CONCENTRATION: 5000 µg/plate
CYTOTOXIC CONCENTRATION:
- With metabolic activation: > 5000 µg/plate
- Without metabolic activation: > 5000 µg/plate
Test condition : SYSTEM OF TESTING: Bacterial gene mutation assay
- Species/cell type: S. Typhimurium TA97 TA98, TA100,
- Deficiences/Proficiences: His deficient
- Metabolic activation system: Arochlor induced rat liver post.mitochondrial
fraction (S9).
Pre-Test for toxicity in TA 100
Solvent: water
- Concentrations: 8, 40, 200, 1000, 5000 µg/plate
- Number of replicates: 3
- Positive controls: 2-nitrofluorene (TA98 - S9), sodium azide (TA100 - S9),
9-aminoacridine (TA97, -S9), 2-aminoanthracene (all strains + S9)
- Negative control groups: solvent: water
CRITERIA FOR EVALUATING RESULTS: twofold increase in revertants
compared to concurrent controls indicates positive result.
STATISTICAL METHODS: F-test and regression analysis in case of
positive results.
Reliability : (2) valid with restrictions
3 strains only tested
Flag : Material Safety Dataset, Critical study for SIDS endpoint
07.12.2005 (7)
5.6 GENETIC TOXICITY ‘IN VIVO‘
Type : other
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Remark : As sodium and potassium methylates rapidly hydrolyse in water to
methanol and sodium or potassium hydroxide respectively, the data of the
hydrolysis products are relevant for this substance as well. SIDS dossiers,
SIARs and SIAPs are available for the degradation products.
19.10.2005 (23) (25) (26)
5.7 CARCINOGENICITY
Species : other
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Exposure period :
100
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