Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
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OECD SIDS<br />
POTASSIUM METHANOLATE<br />
5. TOXICITY ID: 865-33-8<br />
DATE: 28.06.2006<br />
Number: 12<br />
ADMINISTRATION:<br />
- Type of exposure: inhalation of an atmosphere enriched with the volatile<br />
components at 20 °C. 200 l/h air were piped through a 5 cm layer of the<br />
product.<br />
Reliability : (2) valid with restrictions<br />
Well documented report, details missing.<br />
Flag : Critical study for SIDS endpoint<br />
05.08.2005 (2)<br />
Type : other: acute inhalation risk test (IRT)<br />
Value :<br />
Species : rat<br />
Strain : no data<br />
Sex : no data<br />
Number of animals : 12<br />
Vehicle :<br />
Doses : dust enriched atmosphere at room temperature<br />
Exposure time : 7 hour(s)<br />
Method : other: IRT<br />
Year : 1979<br />
GLP : no<br />
Test substance : other TS: <strong>Sodium</strong> methylate<br />
Result : No mortality.<br />
No symptoms were observed during the study.<br />
Pathological examination at termination of the study did not reveal any<br />
macroscopic organ changes.<br />
Test condition : Inhalation of an dust enriched atmosphere at room temperature. 200 l<br />
air/hour were piped through a 5 cm layer of the product.<br />
Test substance : <strong>Sodium</strong> methylate as prescribed by 1.1 - 1.4 of CAS 124-41-4<br />
Reliability : (2) valid with restrictions<br />
Well documented report, details missing.<br />
Flag : Critical study for SIDS endpoint<br />
05.08.2005 (4)<br />
5.1.3 ACUTE DERMAL TOXICITY<br />
Type : LD50<br />
Value : > 2000 - mg/kg bw<br />
Species : rat<br />
Strain : Sprague-Dawley<br />
Sex : male/female<br />
Number of animals : 6<br />
Vehicle : water<br />
Doses : 1000, 2000 mg/kg bw<br />
Method : other<br />
Year : 1979<br />
GLP : no<br />
Test substance : other TS: <strong>Sodium</strong> methylate 50% aqueous solution<br />
Remark : As the substance was tested in aqeous solution and sodium methylate<br />
hydrolyses rapidly to methanol and sodium hydroxide, in fact the hydrolysis<br />
products have been tested.<br />
Result : MORTALITY: No deaths occurred at either dose level<br />
CLINICAL SIGNS: irregular breathing and bad general condition. Skin:<br />
necrosis after the 24 hour application.<br />
NECROPSY FINDINGS:<br />
No macroscopic organ changes apart from the skin necrosis were<br />
observed.<br />
UNEP PUBLICATIONS 95