Sodium methanolate - ipcs inchem

OECD SIDS
POTASSIUM METHANOLATE
5. TOXICITY ID: 865-33-8
DATE: 28.06.2006
Test condition : TEST ORGANISMS: male and female Sprague-Dawley rats, SPF
- Source: Hagemann, Extertal
- Weight at study initiation: males: 220 g, females 190 g
ADMINISTRATION: as 50% solution in water
- Area covered: 50 cm2
- Occlusion: yes, 24 hours
- Vehicle: water
- Concentration in vehicle: 50%
- Doses: 1000 and 2000 mg/kg bw
- Removal of test substance: after 24 hours with lukewarm water or
water/lutrol
EXAMINATIONS:
Mortalitiy within 14 days
Clinical symptoms
Necropsy and macroscopic examination at termination.
Test substance : Sodium methylate krist., BASF tested as 50% solution in water
Reliability : (2) valid with restrictions
Well documented study.
Flag : Critical study for SIDS endpoint
23.08.2005 (5)
5.1.4 ACUTE TOXICITY, OTHER ROUTES
5.2.1 SKIN IRRITATION
Species : rabbit
Concentration : undiluted
Exposure : no data
Exposure time :
Number of animals : 2
Vehicle :
PDII :
Result : corrosive
Classification : highly corrosive (causes severe burns)
Method : other: not specified
Year : 1978
GLP : no
Test substance : other TS: Sodium methylate 30% in Methanol
Result : Exposure 1 min:
Symptoms after 24 h:
slight necrosis, moderate erythema and oedema
Symptoms after 8 days:
moderate necrosis and desquamation
Exposure 5 min:
Symptoms after 24 h:
moderate necrosis, moderate erythema and oedema.
After 8 days: moderate extended necrosis
15 min: very severe necrosis persisiting after 8 days.
Severe pain reaction shortly after the application of the test substance.
Test condition : Exposure time 1 to 15 min.
Reliability : (2) valid with restrictions
Well documented report, details missing.
Flag : Critical study for SIDS endpoint
24.10.2005 (2)
Species : rabbit
Concentration : 80 %
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