Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
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OECD SIDS<br />
METHANOLATES<br />
Toxicity to algae<br />
A 24-hour test in the alga Scenedesmus subspicatus was performed with sodium <strong>methanolate</strong><br />
according to DIN 38412 part 12 (no GLP, no analytical monitoring). The EC 50 for assimilation<br />
inhibition was calculated to be 302 mg/l, the EC 10 was 24 mg/l and the EC 90 3800 mg/l (Degussa,<br />
1989a).<br />
Additional results to the hydrolyses products are listed in Table 3<br />
Table 3 Toxicity of hydrolysis products to aquatic organisms<br />
Species Parameter Effects Reference<br />
<strong>Sodium</strong> hydroxide:<br />
Leuciscus idus melanotus<br />
Gambussia affanis<br />
(fish)<br />
Ceriodaphnia dubia<br />
Daphnia magna<br />
(invertebrate)<br />
Biomphalaria a. alexandrina<br />
Bulinus truncatus<br />
Lymnea caillaudi<br />
(mollusca)<br />
Ophryotrocha diadema<br />
(marine polychaete)<br />
48h-LC 50<br />
96h-LC 50<br />
48h-LC 50<br />
TTC*<br />
Lethal concentrations<br />
189 mg/l<br />
125 mg/l<br />
40 mg/l<br />
40 – 240 mg/l<br />
450 mg/l<br />
150 mg/l<br />
150 mg/l<br />
OECD, 2002<br />
OECD, 2002<br />
OECD, 2002<br />
48h-LC 50 33 - 100 mg/l OECD, 2002<br />
Potassium hydroxide:<br />
Gambusia affinis<br />
Poecilia reticulata<br />
(fish)<br />
96h-LC 50<br />
24h-LC 50<br />
80 mg/l<br />
165 mg/l<br />
OECD, 2001<br />
Methanol:<br />
Different fish species 96h-LC 50 15 400 – 29 400 mg/l OECD, 2004<br />
Daphnia magna<br />
(invertebrate)<br />
Chlorella pyrenoidosa<br />
(algae)<br />
* toxicity threshold concentration<br />
Chronic Toxicity Test Results<br />
Several 24h- and 48h-EC 50<br />
24h-EC 50<br />
> 10 000 mg/l<br />
21 400 mg/l<br />
OECD, 2004<br />
10 – 14d- ErC 50 28 440 mg/l OECD, 2004<br />
Only one chronic toxicity study which was not considered reliable (reliability 3) was reported for<br />
NaOH. An adverse effect on survival rate, growth and fecundity as well as the quality of progeny<br />
was found in Lebistes reticulatus between 25 and 100 mg/l of NaOH (OECD, 2002).<br />
Toxicity to Microorganisms<br />
The inhibition of bacterial metabolism in a bacterial mixed culture according to DIN 38412 part 12<br />
was studied with sodium <strong>methanolate</strong>. The 24-hour EC 50 was 97 mg/l, the EC 10 38 mg/l and the<br />
EC 90 246.9 mg/l.<br />
<strong>Sodium</strong> hydroxide<br />
The 15-minute-EC 50 for Photobacterium phosphoreum in the Microtox system was 22 mg/l. The<br />
test medium was 2 % NaCl indicating that the medium was not buffered. The effect of NaOH on<br />
UNEP PUBLICATIONS 29