Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
Sodium methanolate - ipcs inchem
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OECD SIDS<br />
POTASSIUM METHANOLATE<br />
5. TOXICITY ID: 865-33-8<br />
DATE: 28.06.2006<br />
Value : = 2037 mg/kg bw<br />
Species : rat<br />
Strain : Sprague-Dawley<br />
Sex : male<br />
Number of animals : 10<br />
Vehicle : other: corn oil<br />
Doses : 1500, 1800, 2250, 2380, 2600, 3400 mg/kg bw<br />
Method : other: similar to OECD Guide-line 401<br />
Year : 1982<br />
GLP : no data<br />
Test substance : other TS: sodium methylate<br />
Result : MORTALITY:<br />
Dose [mg/kg bw] Mortality<br />
3400 10/10<br />
2600 10/10<br />
2380 8/10<br />
2250 2/10<br />
1800 5/10<br />
1500 1/10<br />
- Time of death: up to 14 days after dosing<br />
CLINICAL SIGNS:<br />
All dose levels: labored breathing, weakness, wet and stained perianal<br />
area, chromodacryorrhea, ruffled fur.<br />
from 1800 mg/kg bw: salivation and lethargy<br />
from 2380 mg/kg bw: Ataxia<br />
from 2600 mg/kg bw: lacrimation<br />
Body weight: loss from day 9<br />
Test condition : TEST ORGANISMS: Male Spraque Dawley rats crl:CD<br />
- Age: young adult<br />
- Weight at study initiation: 238 - 252<br />
ADMINISTRATION:<br />
- concentration: 20 to 30% Suspension in corn oil by gavage<br />
- Volume administered: 1.83 to 2.7 ml<br />
- Post dose observation period: 14 days<br />
EXAMINATIONS: clinical observations, body weight<br />
Reliability : (2) valid with restrictions<br />
Comparable to guideline study, no necropsy findings reported, no data on<br />
GLP<br />
Flag : Critical study for SIDS endpoint<br />
18.08.2005 (19)<br />
Type : LD50<br />
Value : = 1687 mg/kg bw<br />
Species : rat<br />
Strain : Sprague-Dawley<br />
Sex : male/female<br />
Number of animals : 10<br />
Vehicle : water<br />
Doses : 1000, 1260, 1587, 2000 mg/kg bw<br />
Method : OECD Guide-line 401 "Acute Oral Toxicity"<br />
Year : 1988<br />
GLP : yes<br />
Test substance : other TS: <strong>Sodium</strong> methylate<br />
Remark : As the substance was tested in aqeous solution and sodium methylate<br />
hydrolyses rapidly to methanol and sodium hydroxide, in fact the hydrolysis<br />
products have been tested.<br />
Result : MORTALITY:<br />
Dose [mg/kg bw] Mortality<br />
2000 8/10<br />
92<br />
UNEP PUBLICATIONS