Sodium methanolate - ipcs inchem

OECD SIDS
SODIUM METHANOLATE
5. TOXICITY ID: 124-41-4
DATE: 28.06.2006
Remark : As the substance was tested in aqeous solution and sodium methylate
hydrolyses rapidly to methanol and sodium hydroxide, in fact the hydrolysis
products have been tested.
Result : MORTALITY: No deaths occurred at either dose level
CLINICAL SIGNS: irregular breathing and bad general condition. Skin:
necrosis after the 24 hour application.
NECROPSY FINDINGS:
No macroscopic organ changes apart from the skin necrosis were
observed.
Test condition : TEST ORGANISMS: male and female Sprague-Dawley rats, SPF
- Source: Hagemann, Extertal
- Weight at study initiation: males: 220 g, females 190 g
ADMINISTRATION: as 50% solution in water
- Area covered: 50 cm2
- Occlusion: yes, 24 hours
- Vehicle: water
- Concentration in vehicle: 50%
- Doses: 1000 and 2000 mg/kg bw
- Removal of test substance: after 24 hours with lukewarm water or
water/lutrol
EXAMINATIONS:
Mortalitiy within 14 days
Clinical symptoms
Necropsy and macroscopic examination at termination.
Test substance : Sodium methylate krist., BASF tested as 50% solution in water
Reliability : (2) valid with restrictions
Well documented study.
Flag : Critical study for SIDS endpoint
23.08.2005 (4)
5.1.4 ACUTE TOXICITY, OTHER ROUTES
Type : LD50
Value : = 40 mg/kg bw
Species : mouse
Strain :
Sex :
Number of animals :
Vehicle :
Doses :
Route of admin. : i.p.
Exposure time :
Method : other: not specified
Year : 1979
GLP : no
Test substance : as prescribed by 1.1 - 1.4
Result : Symptoms: uncharacteristic, in the beginning of the observation period
body weight reduction. Deaths occurred within the whole of first week of
the experiment.
No macroscopic findings at necropsy.
Source : BASF AG Ludwigshafen
Test condition : Administration of 0.43 to 14.7 % (G/V) suspensions i.p.
Observation period: 14 days.
Test substance : Natriummethylat krist. 0,43 - 14,7 %ige Suspension in
Lutrol (G/V).
05.08.2005 (3)
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