Sodium methanolate - ipcs inchem

OECD SIDS
SODIUM METHANOLATE
5. TOXICITY ID: 124-41-4
DATE: 28.06.2006
5.4 REPEATED DOSE TOXICITY
Method : other: rational
Year :
GLP :
Test substance :
Remark : No data on repeated dose toxicity of sodium and potassium methanolate
are available. The tolerable dose levels will be determined by the corrosive
nature of the substances. At sub irritant concentrations the toxicity of K+ or
Na+ ions and OH- ions are unlikely to contribute to the effects to be
expected after repeated exposure. The specific ocular and CNS toxicity of
methanol in primates is based on the accumulation of formate in blood.
Formate accumulation in primates has been observed at methanol doses
greater than 500 mg/kg. The corresponding dose levels for sodium and
potassium methanolate that would lead to accumulation of formate in
primates would be 840 and 1000 mg/kg bw. Such dose levels are already
in the acutely toxic dose range. Due to the corrosive nature of the
methanolates it is unlikely that exposure to methanolates could result in an
uptake of toxic doses of methanol.
02.12.2005 (35) (37) (38)
5.5 GENETIC TOXICITY ‘IN VITRO‘
Type : other
System of testing :
Test concentration :
Cycotoxic concentr. :
Metabolic activation :
Result :
Method :
Year :
GLP :
Test substance :
Remark : As sodium and potassium methylates rapidly hydrolyse in water to
methanol and sodium or potassium hydroxide respectively, the data of the
hydrolysis products are relevant for this substance as well. SIDS dossiers,
SIARs and SIAPs are available for the degradation products.
Due to the rapid hydrolysis of methanolates in in vitro test systems and
tissue water in vivo, data for the hydrolysis products are relevant for
methanolates as well. For sodium and potassium hydroxide there is no
evidence for a mutagenic potential. For methanol the weight of evidence
suggests that the substance is unlikely to have any relevant mutagenic
activity. Therefore it can be concluded that there should at present be no
concern with regard to a mutagenic activity of sodium or potassium
methanolate.
02.12.2005 (35) (37) (38)
Type : Ames test
System of testing : S. typhimurium TA97, 98, 100
Test concentration : 8 - 5000 µg/plate
Cycotoxic concentr. : > 5000 µg/plate
Metabolic activation : with and without
Result : negative
Method : other: comparable to OECD Guide-line 471, but 3 strains only tested
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