Whipple's disease and Tropheryma whipplei
Whipple's disease and Tropheryma whipplei
Whipple's disease and Tropheryma whipplei
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Evolution <strong>and</strong> prognosis of the <strong>disease</strong>?<br />
In lack of adapted antibiotic treatment, the evolution of<br />
Whipple’s <strong>disease</strong> is fatal.<br />
For the patients treated adequately, the diarrhea<br />
disappeared quickly, in less of one week. The arthralgia<br />
regress between 2 to 3 weeks. For neurological signs, their<br />
regression is generally observed, more than 3 weeks after the<br />
beginning of the adapted antibiotic treatment. Moreover,<br />
neurological sequellaes are frequently observed.<br />
After the end of the antibiotic treatment, relapses are<br />
observed, mainly, in the brain. Their frequency has been<br />
diversely estimated between 2 <strong>and</strong> 35%.<br />
After the end of the antibiotic treatment, it is better to<br />
follow the patients during his entire life.<br />
References:<br />
-Whipple’s <strong>disease</strong>. Marth T, <strong>and</strong> D Raoult. Lancet 2003: 18, 239-246.
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