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Whipple's disease and Tropheryma whipplei

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Follow-up of the patients after the end of the<br />

treatment?<br />

-Every month for 3 months :<br />

Hemogram, transaminases, gammaglutamyltranspeptidase <strong>and</strong><br />

creatinine blood levels. Immunohistochemistry of monocytes,<br />

saliva, blood <strong>and</strong> stools for PCR.<br />

Necessity to perform one month after the end of treatment :<br />

Small-bowel biopsy for immunohistochemistry <strong>and</strong> PCR, lumbar<br />

puncture for PCR in the CSF for all patients with Whipple’s<br />

<strong>disease</strong>.<br />

-Every 3 months for 5 years :<br />

Hemogram, transaminases, gammaglutamyltranspeptidase <strong>and</strong><br />

creatinine blood levels. Immunohistochemistry of monocytes,<br />

saliva, blood <strong>and</strong> stools for PCR.<br />

Besides, necessity to perform one time per year :<br />

Small-bowel biopsy for immunohistochemistry <strong>and</strong> PCR, lumbar<br />

puncture for PCR in the CSF for all patients with Whipple’s<br />

<strong>disease</strong>.<br />

-One time per year :<br />

Hemogram, transaminases, gammaglutamyltranspeptidase <strong>and</strong><br />

creatinine blood levels. Immunohistochemistry of monocytes,<br />

saliva, blood <strong>and</strong> stools for PCR.<br />

Small-bowel biopsy for immunohistochemistry <strong>and</strong> PCR, lumbar<br />

puncture for PCR in the CSF for all patients with Whipple’s<br />

<strong>disease</strong>.

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