Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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Example of TDM (3) Mercaptopurine • Children with ALL (repeated sampling) • Relapse associated with Cp max 363ng/hr.ml Hayder S etal, Ther drug Monit 1989, 11, 617- 622
Genetic Polymorphisms in Metabolizing Enzymes www.sciencemag.org/feature/data/1044449.shl Science 1999;286:487-91
Page 1 and 2: Therapeutic Drug Monitoring in Onco
Page 3 and 4: Cancer Chemotherapy • High toxici
Page 5 and 6: Pharmacokinetics • Describes the
Page 7 and 8: Therapeutic Drug Monitoring (TDM)
Page 9 and 10: Requirements for TDM • No direct
Page 11 and 12: TDM : Procedure • Take sample: -
Page 13 and 14: TDM- “The Old Way” • Give sta
Page 15 and 16: How Accurate/Relevant is BSA-Based
Page 17 and 18: Problems with TDM in Oncology • P
Page 19: Examples of TDM (2) 5-Fluorouracil
Page 24 and 25: Mercaptopurine Catabolism Liver GI
Page 26 and 27: PK-PD Relationships in Cancer Chemo
Page 29 and 30: Carboplatin dose for manageable hae
Page 35 and 36: Carboplatin Continuous Infusion PK-
Page 37 and 38: Bayesian Theory Rev. Thomas Bayes,
Page 39 and 40: Bayesian Adaptive Dosing Prospectiv

Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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