Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
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Cl<strong>in</strong>ical Pharmacok<strong>in</strong>etics<br />
• Many drug doses are empirical<br />
• <strong>Drug</strong> elim<strong>in</strong>ation (and hence efficacy<br />
and <strong>to</strong>xicity) varies between patients.<br />
• Body wt. and BSA – not always good<br />
<strong>in</strong>dica<strong>to</strong>rs of drug clearance<br />
• Some drugs have narrow therapeutic<br />
w<strong>in</strong>dow E.g. cy<strong>to</strong><strong>to</strong>xic drugs used <strong>in</strong><br />
cancer chemotherapy
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