Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
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TDM <strong>in</strong> <strong>Oncology</strong>: Confound<strong>in</strong>g<br />
Fac<strong>to</strong>rs<br />
• Genetic polymorphism<br />
• <strong>Drug</strong> resistance<br />
• <strong>Drug</strong> <strong>in</strong>teractions<br />
• Assay difficulties<br />
• Active metabolites<br />
• Some drugs are pro-drugs (e.g.<br />
cyclophosphamide)
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