Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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Carboplatin continuous infusion with Synchronous Radiotherapy Carboplatin 25-40mg/day x 5days x 4 courses by continuous infusion + radiation (40Gy) , fractionated
Page 1 and 2: Therapeutic Drug Monitoring in Onco
Page 3 and 4: Cancer Chemotherapy • High toxici
Page 5 and 6: Pharmacokinetics • Describes the
Page 7 and 8: Therapeutic Drug Monitoring (TDM)
Page 9 and 10: Requirements for TDM • No direct
Page 11 and 12: TDM : Procedure • Take sample: -
Page 13 and 14: TDM- “The Old Way” • Give sta
Page 15 and 16: How Accurate/Relevant is BSA-Based
Page 17 and 18: Problems with TDM in Oncology • P
Page 19: Examples of TDM (2) 5-Fluorouracil
Page 22 and 23: Example of TDM (3) Mercaptopurine
Page 24 and 25: Mercaptopurine Catabolism Liver GI
Page 26 and 27: PK-PD Relationships in Cancer Chemo
Page 29: Carboplatin dose for manageable hae
Page 36 and 37: TDM - The New Way • Collect infor
Page 38 and 39: Bayesian Adaptive Dose Bayesian App
Page 40: Conclusions • Expectation of TDM

Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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