Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
Therapeutic Drug Monitoring in Oncology: The key to individualised ...
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<strong><strong>The</strong>rapeutic</strong> <strong>Drug</strong> <strong>Moni<strong>to</strong>r<strong>in</strong>g</strong><br />
(TDM)<br />
• Large variation <strong>in</strong> drug plasma<br />
concentration between <strong>in</strong>dividuals for a<br />
given dose;<br />
Formulation<br />
<strong>Drug</strong> <strong>in</strong>teractions<br />
Life-style (eg diet, smok<strong>in</strong>g)<br />
Disease (renal & hepatic function)<br />
Genetic variation (<strong>in</strong> metabolism)
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