Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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Bayesian Adaptive Dose Bayesian Approach: Prior probability New Info Objective function Posterior probability Goals Control therapy In Practice: Population model Drug levels Prior + New info. Individual model Patient specific Calculate dose
Bayesian Adaptive Dosing Prospective Review Genetic Factors for Drug Disposition /Response/Toxicity Test – dose TDM Conventional Medication Review Patient Specific Factors (eg organ function,drug – drug interactions, cautions, life-style influences etc etc) Combination = Optimal Pharmacotherapy?
Page 1 and 2: Therapeutic Drug Monitoring in Onco
Page 3 and 4: Cancer Chemotherapy • High toxici
Page 5 and 6: Pharmacokinetics • Describes the
Page 7 and 8: Therapeutic Drug Monitoring (TDM)
Page 9 and 10: Requirements for TDM • No direct
Page 11 and 12: TDM : Procedure • Take sample: -
Page 13 and 14: TDM- “The Old Way” • Give sta
Page 15 and 16: How Accurate/Relevant is BSA-Based
Page 17 and 18: Problems with TDM in Oncology • P
Page 19: Examples of TDM (2) 5-Fluorouracil
Page 22 and 23: Example of TDM (3) Mercaptopurine
Page 24 and 25: Mercaptopurine Catabolism Liver GI
Page 26 and 27: PK-PD Relationships in Cancer Chemo
Page 29 and 30: Carboplatin dose for manageable hae
Page 35 and 36: Carboplatin Continuous Infusion PK-
Page 37: Bayesian Theory Rev. Thomas Bayes,

Therapeutic Drug Monitoring in Oncology: The key to individualised ...

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