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2008 Pittcon Final Program - Pittcon Web Archives

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ORGANIZED CONTRIBUTED<br />

Session 1410<br />

SESSION<br />

Current Status and Trends in the Application of Liquid<br />

Chromatography (LC and UHPLC) Hyphenated with Tandem<br />

Mass Spectrometry for Pharmaceutical Analysis - arranged by<br />

Arindam Roy, Covidien<br />

Tuesday Afternoon, Room 245<br />

Arindam Roy, Covidien, Presiding<br />

1:30 (1410-1) Tandem MS with Evaporative Light Scattering<br />

Detection (ELSD): A Powerful Analytical Combination for the Analysis of<br />

Select Pharmaceuticals JOHN EDWIN GEORGE, Varian, Inc., Fran Lai<br />

1:50 (1410-2) Application of LC/MS as an Everyday Tool in the<br />

Analytical Process Development of API YANQUN ZHAO, Abbott<br />

Laboratories, Wayne A Pritts, Shuhong Zhang<br />

2:10 (1410-3) The LTQ Orbitrap: Defining Its Place in the Drug<br />

Development and Impurity Analysis Workflows BRENDA KESLER, Thermo<br />

Fisher Scientific<br />

2:30 (1410-4) Addressing the NEED for SPEED: High Throughput<br />

and High Confidence with Novel LC-MS/MS Solutions ROBERT IAN ELLIS,<br />

Applied Biosystems/MDS Sciex<br />

2:50 Recess<br />

3:05 (1410-5) The Application of Capillary LC/MS Using Nanospray<br />

for the Profiling of Impurities and Degradants ROBYN A ROURICK,<br />

Kalypsys, Inc., John P Walsh, Gary Valaskovic, Mike Lee<br />

3:25 (1410-6) Automated Sample Enrichment and High Sensitivity<br />

Analysis of DMPK Samples Using HPLC-Chip QQQ MS GEORGES L<br />

GAUTHIER, Agilent Technologies, Stephan Buckenmaier, Martin Vollmer<br />

3:45 (1410-7) Realizing the Benefits of Sub 2µm Particle LC<br />

Hyphenated with MS/MS for Pharmaceutical Analysis ROBERT S PLUMB,<br />

Waters Corporation<br />

4:05 (1410-8) Effective Use of LC-MSn Molecular Fingerprinting for<br />

the Rapid Structural Identification of Pharmaceutical Impurities MIN LI,<br />

Schering-Plough, Abu M Rustum<br />

ORGANIZED CONTRIBUTED<br />

Session 1420<br />

SESSION<br />

Pharmaceutical Analysis: Latest Trends in Taste and Flavor<br />

Assessment in Drug Product Formulations (Half Session) -<br />

arranged by Kenneth J Norris, Pfizer<br />

Tuesday Afternoon, Room 261<br />

Kenneth J Norris, Pfizer, Presiding<br />

1:30 (1420-1) Analytical Methods for the Analysis of Flavors in<br />

Pharmaceuticals KENNETH J NORRIS, Pfizer<br />

1:50 (1420-2) Improving the Manufacturing Quality Consistency of<br />

Food and Soft Drink Products Using the Electronic Nose and Tongue<br />

JEAN-CHRISTOPHE MIFSUD, Alpha MOS, Vincent Schmitt<br />

2:10 (1420-3) Drug Product Characterization by Macropixel<br />

Analysis of Chemical Images MAZEN L HAMAD, U.S. Food and Drug<br />

Administration, Christopher D Ellison, Mansoor A Khan, Lyon C Robbe<br />

2:30 (1420-4) Overview of Electronic Tongue and Nose<br />

Applications for Improving the Taste and Flavor Acceptance of<br />

Pharmaceutical Products VINCENT SCHMITT, Alpha MOS<br />

ORAL SESSION Session 1430<br />

Bioanalytical Separations II<br />

Tuesday Afternoon, Room 263<br />

Mary Ellen P McNally, DuPont Crop Protection, Presiding<br />

1:30 (1430-1) Superoxide Production in Mitochondria XIN XU,<br />

University of Minnesota, Edgar A Arriaga<br />

1:50 (1430-2) Separation and Quantification of Modified<br />

Nucleosides in Urine Samples by Capillary Electrophoresis with Laserinduced<br />

Fluorescence Detection YONGQING JIANG, University of Missouri,<br />

Rolla, Heng Liang, Yinfa Ma<br />

2:10 (1430-3) Cation Separations by Capillary Electrophoresis<br />

Using Organic Salts and Modifiers in the Background Electrolyte STEVEN<br />

A STEINER, University of Wisconsin, Platteville, James S Fritz<br />

2:30 (1430-4) Possibilities in the Identification and Quantification<br />

of Flavonoids Simultaneously with Acids, Sugars and Sugar Alcohols in<br />

Natural Matrices by GC-MS(MS) IBOLYA MOLNÁR-PERL, L. Eötvös<br />

University<br />

2:50 Recess<br />

3:05 (1430-5) On-line Method for Determining In Vitro Amino Acid<br />

Flux in Sub-Minute Time Scales Using Fast Micellar Electrokinetic<br />

Chromatography JASON GREENE, Vanderbilt University, John P Wilkswo<br />

3:25 (1430-6) Isolation and Detection of Calcium Phosphate<br />

Crystals from Synovial Fluid Using Bisphosphonate-Modified Magnetic<br />

Beads AARON HERNANDEZ-SANTANA, Dublin City University, Adedayo<br />

Oyinloye, Alexander I Yavorskyy, Geraldine M McCarthy, Alastair D Smith,<br />

Gillian P McMahon<br />

3:45 (1430-7) Water-Soluble Vitamin and Amino Acid Analysis in<br />

Cell Culture Media Using Separation Technology JO-ANN M JABLONSKI,<br />

Waters Corporation, Thomas E Wheat, Paula Hong, Diane M Diehl<br />

4:05 (1430-8) High-Speed Amino Acid Analysis (AAA) on 1.8<br />

Micron Reversed-Phase (RP) Columns JOHN W HENDERSON, Agilent<br />

Technologies, Cliff Woodward, Todd Wielgos<br />

ORAL SESSION Session 1440<br />

Clinical/Toxicology<br />

Tuesday Afternoon, Room 264<br />

Dutt V Vinjamoori, Martek Biosciences Corporation, Presiding<br />

1:30 (1440-1) A New Method for the Analysis of Physiological<br />

Amino Acids PAULA HONG, Waters Corporation, Thomas E Wheat, Diane M<br />

Diehl<br />

1:50 (1440-2) Rapid and Facile Detection of Stimulants and Their<br />

Metabolites in Urine Using Solid Phase Extraction-Thermal Desorption-Ion<br />

Mobility Spectrometry with Alternating Least Squares YAO LU, Ohio<br />

University, Peter de B Harrington<br />

2:10 (1440-3) Rapid Measure of Drug-Drug Interaction Utilizing<br />

Generic Gradient Ultra Performance Liquid Chromatography and Tandem<br />

Mass Spectrometry PAUL D RAINVILLE, Waters Corporation, Robert S<br />

Plumb<br />

2:30 (1440-4) Determination of Ratio of Testosterone and Epi-<br />

Testosterone by SPME/LC/MS Method YANWEI ZHAN, University of<br />

Waterloo, Janusz Pawliszyn<br />

2:50 Recess<br />

3:05 (1440-5) Assessment of Current Atomic Spectrometric<br />

Methods for the Determination of Lead in Blood via Performance in the<br />

New York State Proficiency Testing <strong>Program</strong> PATRICK J PARSONS, New<br />

York State Dept of Health, Ciaran Geraghty, Miles Lewis, Christopher Palmer,<br />

Mary F Verostek<br />

3:25 (1440-6) Gradation of Gliomas: A 1H NMR Metabolic Study<br />

VERONIQUE GILARD, University Paul Sabatier, Myriam Malet-Martino, Olivier<br />

Robert, Jean Sabatier, Robert Martino<br />

3:45 (1440-7) Monitoring of Propofol Concentrations in Breath and<br />

Blood by SPME-GC-MS and PTR-MS: Chance and Limitations of a New<br />

Clinical Tool WOLFRAM MIEKISCH, University of Rostock, Patricia Fuchs,<br />

Svend Kamysek, Maren Mieth, Jochen Schubert<br />

4:05 (1440-8) Functional Groups: A Major Deciding Factor for<br />

Analytical Method Development PADINJAREKUTTU RAMAN PILLAI<br />

RAVIKUMAR, Public Health Laboratories/NYC DOH, Sara B Beatrice<br />

ORAL SESSION Session 1450<br />

Development and Applications of Nanotechnology and<br />

Microscopy<br />

Tuesday Afternoon, Room 271<br />

James Manner, Retired - PPG Industries, Inc., Presiding<br />

1:30 (1450-1) Nano-Structured Scaffolds as Synthetic Models of<br />

Enzyme Complexes JACQUELINE KEIGHRON, The Pennsylvania State<br />

University, Lisa M Dominak, Christine Keating

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