LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer
LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer
LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer
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<strong>High</strong> Sensitivity: Derivatization <strong>of</strong> <strong>Protein</strong>s<br />
with FL dye<br />
• Replaces on-chip staining with <strong>of</strong>f-chip labeling in order to increase sensitivity by<br />
10X or more<br />
• NHS esters reaction with amine groups <strong>of</strong> lysine residues<br />
O O<br />
N O<br />
Dye<br />
NH 3<br />
O NH<br />
Dye<br />
MAb<br />
Dye Succinimidyl Ester<br />
O<br />
Intact Antibody<br />
Reduction<br />
2 + 2<br />
O<br />
N<br />
O<br />
O<br />
O<br />
Dye<br />
NH<br />
NH<br />
O<br />
Dye<br />
Dye<br />
MAb<br />
Heavy Light<br />
Chain Chain<br />
Dye Succinimidyl Ester<br />
O<br />
HC and LC<br />
17
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