LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer

Low Level Impurity Detection: Covalent
Off-Chip Staining
i
• Carbonic anhydrase was spiked into mAb sample at 0.01%, 0.05% and 0.5% of the
total protein at 1 mg/ml.
• ~ 100X improvement in sensitivity!
0.5%
0.05%
0.01%
Background mAb trace
Spiked CA
20